Lidan You, CV

Curriculum Vitae of Lidan You

Department of Mechanical and Industrial Engineering

Institute of Biomaterials and Biomedical Engineering

University of Toronto

Revised date:          March 23, 2019

Section 1 – General Information

Name:                                      Lidan You

Mailing Address:                   5 King’s College Road

Toronto, ON M5S 3G8

Office address:                       5 King’s College Road, Room 316

Toronto, ON M5S 3G8

(416) 978-5736 (tel)

(416) 978-7753 (departmental fax)

Laboratory addresses:         170 College Street

Rooms MB308

Toronto, ON M5S 3E3

(416) 976-0943 (tel)

E-mail:                               youlidan@mie.utoronto.ca

Website:                                                 http://cbl.mie.utoronto.ca/

1.2        Date of Birth:                              12/11/1970

Degree Institution Department Thesis Field     Year
B.Sc. Peking University  (PKU) Mechanical Engineering   1994
M.Sc. Peking University (PKU) Mechanical Engineering Measurement of Viscoelasticity of a Biofluid Using a Co-axial Rheometer and Bending Induced Fluid Flow in Bone 1997
Ph.D. City University of New York Mechanical Engineering A New View of Mechanotransduction in Bone Cell 2002

1.4        Full Time Employment, Sabbatical Leave and University Administrative Functions

Dates Employer Position
Sep. 1994 ­­­­­– June 1997 Department of Mechanical Engineering, Peking University Research Assistant
Sep. 1997 ­­­­­– Jan. 2002 New York Center for Biomedical Engineering,                          City College of City University of New York;                 Department of Orthopaedics, Mount Sinai  School of Medicine Research Assistant
Feb.  2002 ­­­­­– Oct. 2006 Department of Mechanical Engineering, Stanford University Postdoctoral Fellow
Nov. 2006 ­­­­­– Jun. 2012 Department of Mechanical and Industrial Engineering, University of Toronto, Assistant Professor (primary appointment)
Nov. 2006 ­­­­­– Jun. 2012 Institute of Biomaterials and Bioengineering, University of Toronto Assistant Professor (secondary appointment)
Jul. 2012 ­­­­­– present Department of Mechanical and Industrial Engineering, University of Toronto, Associate Professor (primary appointment)
Jul. 2012 ­­­­­– present Institute of Biomaterials and Bioengineering, University of Toronto Associate Professor (secondary appointment)
Jul. 2012 – present Toronto Musculoskeletal Center, University of Toronto Associate Professor (graduate faculty member)
Apr. 2013– present State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences Visiting Associate Research Fellow
Jul. 2013 – present Music and Health Research Collabortory (MaHRC), Faculty of Music, University of Toronto Associate Professor (status only)
Jul. 2013 – Jun. 2014 Department of Mechanical and Industrial Engineering, University of Toronto Sabbatical Leave

1.5        Lifetime Academic, Research and Professional Honours

Date Award Title Awarded By
1997 Guang Hua Student Scholarship Peking University
1998 Science/Engineering Fellowship City University of New York
2001 Harold Shames Biomedical Engineering Awards  for Graduate  Academic Excellence City University of New York
2004 Excellent Poster Award  California Tissue Engineering Meeting
2004 Young Investigator Award International Bone Fluid Flow Workshop
2006 New Investigator Recognition Awards finalist Orthopaedic Research Society
2007 Young Investigator award International Bone Fluid Flow Workshop
2010 Early Research Award Ontario Ministry of Research and Innovation
2011 The G.H. Duggan Medal Canadian Society of Mechanical Engineering
2015 Elected Fellow Canadian Society of Mechanical Engineering
2015 Globex Fellow Peking University


Section 2 – Publications

Citations and journal impact factors:

For reference, the impact factors of the journals in which I have published or have papers under review are provided below (from ISI Journal Citation Reports; accessed October 28, 2019).

My citation metrics as of October 28, 2019 are:

Number of citations: 1966 (ISI Web of Science) / 3046 (Google Scholar)

h-index: 22/25

Journal Title Impact Factor 5-year Impact Factor Ranking
American Journal of Physiology-Cell Physiology 3.674 3.952 #17/81 PHYSIOLOGY
Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology 1.530 1.595 #10/20 ANATOMY & MORPHOLOGY
Biomicrofluidics 3.357 3.464 #2/31 PHYSICS, FLUIDS & PLASMAS
Biorheology 1.590 2.130 #38/76 ENGINEERING, BIOMEDICAL
Bone 4.461 4.587 #26/124 ENDOCRINOLOGY & METABLOLISM
Cellular and Molecular Bioengineering 1.230 1.674 #59/74 BIOPHYSICS
Chemical Engineering Science 2.337 2.674 #24/133 ENGINEERING, CHEMICAL
Haematologica 5.814 5.653 #5/68  HEMATOLOGY
Journal of Biomechanics 2.496 3.141 #26/74 ENGINEERING, BIOMEDICAL
Journal of Cellular Biochemistry 3.263 3.173 #107/291 BIOCHEMISTRY & MOLEDULAR BIOLOGY
Journal of Orthopaedic Research 2.986 3.221 #6/67 ORTHOPEDICS
Journal of Bone and Mineral Research 6.589 6.520 #12/124 ENDOCRINOLOGY & METABLOLISM
Journal of Micromechanics and Microengineering 1.725 2.045 #17/57 INSTRUMENTS & INSTRUMENTATION
Journal of Visualized Experiments NA NA NA
Lab on a Chip 6.115 5.775 #8/78 BIOCHEMICAL RESEARCH METHODS
ACS nano 12.033 13.774 #9/251 MATERIALS SCIENCE, MULTIDISCIPLINARY
Microsystems & Nanoengineering 5.616 6.019 #3/61 INSTRUMENTS AND INSTRUMENTATION
Nanotechnology 3.672 3.867 #19/136 PHYSICS, APPLIED
Scientific World Journal 1.219 1.3 #16/55 MULTIDISCIPLINARY SCIENCES
IEEE Robotics and Automation Letters      
Integrative Biology 3.294 3.460  

2.1        Refereed Journal Publications (trainee names underlined)

  1. Published/Accepted  
  # citations
ISI/ Google
1.  Lidan You, Stephen C. Cowin, Mitchell B. Schaffler, and Sheldon Weinbaum (2001) “A model for strain amplification in the actin cytoskeleton of osteocytes due to fluid drag on pericellular matrix” Journal of Biomechanics 34:1375 –1386. 250/389
2. Sheldon Weinbaum, Peng Guo, and Lidan You (2001) “A new view of mechanotransduction and strain amplification in cells with microvilli and cell processes”. Biorheology 38: 119-142. (Journal Cover Article) 57/83
3. Lidan You, Sheldon Weinbaum, Stephen C. Cowin, Mitchell B. Schaffler (2004) “Ultrastructure of the osteocytes process and its pericellular matrix”. Anatomical Record 278 A(2): 505-513. (Journal Cover Article) 200/277
4. Ying J. Li, Nikhil N. Batra, Lidan You, Stephen C. Meier, Ian A. Coe, Clare E. Yellowley, Christopher R. Jacobs (2004) “Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation”. Journal of Orthopaedic Research 22: 1283-1289. 167/272
5. Nikhil N. Batra, Ying J. Li, Clare E. Yellowley, Lidan You, Amada Malone, Chi Hyun Kim, Christopher R. Jacobs (2005) “Effects of short term recovery periods on fluid induced signaling in osteoblastic cells” Journal of Biomechanics. 38: 1909-1917. 88/138
6. Chi Hyun Kim, Lidan You, Clare E. Yellowley, Christopher R. Jacobs (2006) “Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signalling”. Bone. 39(5): 1043-7. (Top 22 in downloads from Bone from Oct. to Dec. 2006. (Data from ScienceDirect)) 94/163
7. Amanda Malone, Nikhil N. Batra, Giri Shivariam, Ron Kwon, Lidan You, Chi Hyun Kim, Joshua Rodriguez, Kai Jair, Christopher R. Jacobs (2007) “The role of the actin cytoskeleton in oscillatory fluid flow induced signaling in MC3T3-E1 osteoblasts. American Journal of Physiology-Cell Physiology. 292(5):C1830-6. 53/74
8. Lidan You, Sara Temiyasathit, Peling Lee, Chi Hyun Kim, Padmaja Tummala, Wei Yao, Wade Kingery, Amanda M. Malone, Ronald Y. Kwon, Christopher R. Jacobs (2008) “Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading”. Bone. 42(1): 172-179. (Top 10 in downloads from Bone from Jan. to March. 2008. (Data from ScienceDirect)) 183/329
9. Lidan You, Eric Tao, Fritz Prinz, and Christopher R. Jacobs (2008) “3D Microfluidic Approach to Mechanical Stimulation of Osteocyte Processes”, Cellular and Molecular Bioengineering, 1(1): 103-107. (Top 19 in downloads from Cellular and Molecular Bioengineering from Sep. 23 to Sep. 29, 2011. (Data from Springer (http://www.springer.com/engineering/biomedical+eng/journal/12195))) 11/15
10. Lidan You, Sara Temiyasathit, Sean R. Coyer, Andreas J. Garcia, Christopher R. Jacobs (2008) “Bone Cells Grown on Micropatterned Surfaces are More Sensitive to Fluid Shear Stress”, Cellular and Molecular Bioengineering. 1(2-3): 182-188. 9/16
11. Wen Li, Lidan You, Mitchell B. Schaffler, Liyun Wang (2009) “The dependency of solute diffusion on molecular weight and shape in intact bone” Bone. 45: 1017–1023 26/41
12. Jian-Huang Chen, Chao Liu, Lidan You (co-corresponding author), Craig A. Simmons (2010) “Boning up on Wolff’s Law: mechanical regulation of the cells that make and maintain bone”, J Biomech. 43:108-118. (Top 9 in downloads from J. of Biomechanics from October 2009 to September 2010. Top 25 in downloads from J. of Biomechanics from October to December 2011.  (Data from ScienceDirect)) 150/281
13. Xiaozhou Zhou; Dawei Liu; Lidan You; Liyun Wang (2010) “Quantifying Fluid Shear Stress in a Rocking Culture Dish” Journal of Biomechanics. 43(8):1598-602 24/39
14. Chao Liu, Yan Zhao, Wing-Yee Cheung, Ronak Gandhi, Liyun Wang, Lidan You (corresponding author) (2010) “Effect of Cyclic Hydraulic Pressure on Osteocytes” Bone. 46(5): 1449-1456. 36/67
15. Esther Lau, Saja Al-Dujaili, Axel Guenther, Dawei Liu, Liyun Wang, Lidan You (corresponding author) (2010) “Effect of Low-magnitude, high-frequency vibration on osteocytes in the regulation of osteoclasts” Bone. 46(6):1508-15. (Top 8 in downloads from Bone from April. to June. 2010. (Data from ScienceDirect)) 91/168  
16. Zhe Lu, Christopher Moraes, Yan Zhao, Lidan You, Craig Simmons, Yu Sun (2010) “A Micromanipulation System for Single Cell Deeposition” 2010 IEEE International Conference on Robotics and Automation. 494-499. 12/29
17. Wing-Yee Cheung, Chao Liu, Rachel M.L. Tonelli-Zasarsky,Craig A. Simmons, Lidan You (corresponding author) (2011) “Osteocyte Apoptosis is Mechanically Regulated and Induces Angiogenesis In Vitro” Journal of Orthopaedic Research. 29(4): 523-530. 38/66  
18. Robert Crawford, Gerard F Jones, Lidan You, Qianhong Wu (2011) “Compression-Dependent Permeability Measurement for Random Soft Porous Media and its Implications to Lift Generation:” Chemical Engineering Science. 66: 294-302 11/19  
19. Esther Lau, Whitaik David Lee, Jason Li, John E. Davies, Qianhong Wu, Liyun Wang,  Lidan You (corresponding author) (2011) “Effect of low-magnitude, high-frequency vibration on the osteogenic differentiation of bone marrow stromal cells” Journal of Orthopaedic Research.29(7): 1075-80. 29/42
20. Saja Al-Dujaili, Esther Lau, Hashem Al-Dujaili, Kyle Tsang, Axel Guenther, Lidan You (corresponding author) (2011)“Apoptotic Osteocytes Regulate Osteoclast Precursor recruitment and differentiation in vitro” Journal of Cellular Biochemistry. 112(9):2412-23. 55/78
21. Sheldon Weinbaum, Mia Mia Thi, Yi Duan, Lidan You (2011) “An integrative view of mechanotransduction in endothelial, epithelial and dendritic bone cells” Cellular and Molecular Bioengineering. 4:510-537. 28/39  
Jason Li, Yaniang Zhang, Steve To, Lidan You (co-corresponding author), Yu Sun (2011) “Effect of Nanowire Number, Diameter, and Doping Density on Nano-FET Biosensor Sensitivity” ACS Nano. 5(8):6661-8. 78/94
Jian Chen, Yi Zheng, Qingyuan Tan, Ehsan Shojaei-Baghini, Yan Liang Zhang, Jason Li, Preethy Prasad, Lidan You, Xiao Yu Wu and Yu Sun (2011) “Classification of cell types using a microfluidic device for mechanical and electrical measurement on single cells” Lab on a Chip. 11:3174-81 98/144
Wing-Yee Cheung, Craig Simmons, Lidan You (Corresponding author) (2012), “Osteocyte apoptosis regulate osteoclast precursor adhesion via osteocytic IL-6 secretion and endothelial ICAM-1 expression” Bone. 50:104-110. 37/55
Jason Li, Emily Rose, Daniel Frances, Yu Sun, Lidan You (Corresponding author) (2012) “Effect of oscillating fluid flow stimulation on osteocyte mRNA expression” Journal of Biomechanics 45(2):247-251. 35/56  
Yan Liang Zhang, Jason Li, Steve To, Yong Zhang, Xuyao Ye, Lidan You, and Yu Sun (2012) “Automated nanomanipulation for nanodevice construction” Nanotechnology 23(6) 065304. 18/27
Bin Deng, Xia Fei Li, Di Yi Chen, Lidan You, Junbo Wang, and Jian Chen (2014) “Parameter Screening in Microfluidics Based Hydrodynamic Single-Cell Trapping” Scientific World Volume 2014, Article ID 929163, 8 pages. 3/4
Chao Wei, Beiyuan Fan, Deyong Chen, Chao Liu, Yuanchen Wei, Bo Huo, Lidan You,  Junbo Wang and Jian Chen (2015) “Osteocyte Culture in Microfluidic Devices”  Biomicrofluidics. 9, 014109 3/6
Jia-Ning Zhang, Yan Zhao, Chao Liu, Elizabeth S. Han, Xue Yu, Darcy Lidington, Steffen-Sebastian Bolz, Lidan You (corresponding author) “The Role of the Sphingosine-1-Phosphate Signaling Pathway in Osteocyte Mechanotransduction” Bone. 2015 Oct. 79: 71-8 10/17
Ashutosh Parajuli, Chao Liu, Wen Li, Xiaoyu Gu, Xiaohan Lai, Christopher Price, Lidan You, X. Lucas Lu, Liyun Wang (2015) “Bone Responses to Mechanical Loading are impaired in Type I Diabetes”  Bone. 2015 Dec; 81: 152-160. 23/31
Victor Sanjit Nirmalanandhan, Rose Hurren, William D. Cameron, Marcela Gronda, Aisha Shamas-Din1, Mark D. Minden, Lidan You , Jonathan V. Rocheleau and Aaron D Schimmer (2015) “Increased pressure alters plasma membrane dynamics and renders AML cells resistant to daunorubicin” Haematologica 2015 Oct; 100(10): e406–e408 4/4
Chao Liu, Xiaoqing Zhang, Michael Wu, Lidan You (Corresponding author) (2015) “Mechanical loading up-regulates early remodeling signals from osteocytes subjected to physical damage”  Journal of Biomechanics  2015 Dec. 16; 48(16):4221-8. 4/7
Jiachen Zhang, Onaizah Onaizah, Kevin Andrew James Middleton, Lidan You, Eric D. Diller (2017) “Reliable Grasping of Three-Dimensional Untethered Mobile Magnetic Microgripper for Autonomous Pick-and-Place” IEEE Robotics and Automation Letters 2017 Apr; 2(2): 835-840 14/21  
Kevin Middleton, Xueting Mei, Saja Al-Dujaili, Axel Guenther, Lidan You (corresponding author) (2017)”Microfluidic co-culture platform for investigating osteocyte-osteoclast signalling during  fluid shear stress mechanostimulation” Journal of Biomechanics, 2017 Jul; 59:35-42 6/18
Kevin Middleton, Avinash Kondiboyina, Michael Borrett, Yi Cui, Xueting Mei, Lidan You (corresponding author) (2018) “Microfluidics approach to investigate the role of dynamic similitude in osteocyte mechanobiology” Journal of Orthopaedic Research 2018 Feb;36(2):663-671. 2/4
Yu-Heng Vivian Ma, Kevin Middleton, Lidan You (Co-Corresponding Author), Yu Sun (2018) “A review of microfluidic approaches for investigating cancer extravasation during metastasis” Microsystems & Nanoengineering (2018) 4, 17104; doi:10.1038/micronano.2017.104 (Journal Cover Article) 12/21
Yu-Heng Vivian Ma, Candy Lam, Shreyash Dalmia, Peter Gao, Jacob Young, Kevin Middleton, Chao Liu, Henry Xu, Lidan You (corresponding author) (2018) “Mechanical regulation of breast cancer migration and apoptosis via direct and indirect osteocyte signaling” Journal of Cellular Biochemistry ul;119(7):5665-5675. 6/9
Yu-Heng Vivian Ma, Liangcheng Xu, Xueting Mei, Kevin Middleton, Lidan You (Corresponding Author) (2019) “Mechanically stimulated osteocytes reduce the bone-metastatic potential of breast cancer cells in vitro by signalling through endothelial cells” Journal of Cellular Biohemistry. 120(5): 7590-7601 1/2
Xueting Mei, Kevin Middleton, Dongsub Shim, Qianqian Wan, Liangcheng Xu, Yu-Heng Vivian Ma, Deepika Devadas, Noosheen Walji, Liyun Wang, Edmond W.K. Young, Lidan You (Corresponding Author) (2019) “Microfluidic Platform for the Investigation of Osteocyte Mechanoregulation of Breast Cancer Bone metastasis” Integrative Biology. 2019 11(4):119-129. (Featured as Editor’s Choice in Science Translational Medicine, 12 Jun 2019, Vol. 11, Issue 496, eaax9564, DOI: 10.1126/scitranslmed.aax9564, https://stm.sciencemag.org/content/11/496/eaax9564) 0/1
Liangcheng Xu, Han Shao, Lidan You (Corresponding Author) (2019) “OCY454 As a New Cell Model for Studying Osteocyte Mechanobiology” Journal of Orthopaedic Research. doi: 10.1002/jor.24302. [Epub ahead of print] 0/0
Dongfang Ouyang, Yonghua Li, Wenqi He, Weicong Lin, Lina Hu, Chen Wang, Liangcheng Xu, Jaewon Park, Lidan You (Corresponding Author) (2019) “Mechanical Segregation and Capturing of Clonal Circulating Plasma Cells in Multiple Myeloma using Micropillar-Integrated Microfluidic Device” Biomicrofluidics, 13(6): 064114. DOI: 10.1063/1.5112050. (Selected as Editor’s Pick; Chosen by the publisher, AIP, for special publicity in the form of a press release) 0/0
  • In revision
  • Submitted

Henry Xu, Lidan You “Magnetic approach in generating local shear stress on cells for mechanobiology study”

  • In preparation:
  • Jia Ning Zhang, Lidan You (Corresponding author) “Mechanical loading effect on osteocyte chemosensitivity” In preparation for Bone
  • Chao Liu, Lidan You (Corresponding author)  “Integrated pressure-shear stress loading chamber for bone cell mechanobiology study” In preparation for Journal of Biomechanics
  • Henry Xu, Lidan You “High throughput microfluidic platform for bone cell mechanobiology study”

2.2   Refereed Conference Papers Published in Proceedings (trainee names underlined)

1.     Lidan You, Stephen C. Cowin, Sheldon Weinbaum (1999) Strain Amplification in the Bone Mechanosensory System. The 1st  Joint BMES/EMBS Conference, Oct. 13-16, Atlanta, GA Proceedings of The First Joint BMES/EMBS conference 1999, 492.

2.     Lidan You, Stephen C. Cowin, Sheldon Weinbaum (1999) Strain Amplification in the Bone Mechanosensory System. 1999 PreORS Meeting in Nanheim, California. Seventh Annual Symposium on Computational Methods in Orthopaedic Biomechanics, 1999, 12.

3.     Lidan You, Stephen C. Cowin, Sheldon Weinbaum (1999) Strain Amplification in the Bone Mechanosensory System. 1999 International Mechanical Engineering Congress & Exposition in Nashville, Tennessee. The Proceedings of the 1999 International Mechanical Engineering Congress and Exposition, Bed-Vol. 43.

4.     Lidan You, Stephen C. Cowin, Mitchell B. Schaffler, Sheldon Weinbaum (2000) Strain amplification in bone. Biomedical Engineering Society 2000 Annual Fall Meeting, Oct. 12-14, Seattle, Washington. Annals of Biomedical Engineering, 28 (Suppl. 1): S-6.

5.     Lidan You, Stephen C. Cowin, Mitchell B. Schaffler, Sheldon Weinbaum (2001) Fluid flow induced strain amplification in bone cells. Transaction of the 47th Annual Meeting of Orthopaedic Research Society. 26, 563.

6.     Lidan You (Invited speaker), Sheldon Weinbaum, Stephen C. Cowin, Mitchell B. Schaffler (2002) A New Understanding of Osteocyte Process Ultrastructure. The  24th Annual International Conference of the EMBS and Annual Fall Meeting of the BMES, Proceedings of the Second Joint EMBS/BMES Conference Houston, TX, USA. Page 589, paper 117.

7.     Lidan You, Sheldon Weinbaum, Stephen C. Cowin, Mitchell B. Schaffler (2002) Ultrastructure of osteocyte process. The 24th Annual Meeting of the American Society for Bone and Mineral Research in San Antonio, TX.  Journal of Bone and Mineral Research, 17 (Suppl 1): s352.

8.     Lidan You, Ying J. Li, Nikhil N Batra, Christopher R. Jacobs (2003) The effect of oscillatory fluid flow on human marrow stromal cell proliferation. Transactions of the 2003 Summer Bioengineering Conference, 267.

9.     Lidan You, Ying J. Li, Nikhil N Batra, Christopher R. Jacobs (2003) Design of a 3D microfluidics system for loading fluid flow on osteocyte process in vitro. Transactions of the 2003 Summer Bioengineering Conference, 695.

10.   Nikhil N Batra, Ying J. Li, Clare E. Yellowley, Lidan You, Christopher R. Jacobs (2003) Short term recovery periods lead to multiple oscillatory fluid flow induced intracellular calcium oscillations in osteoblastic cells. Transactions of the 2003 Summer Bioengineering Conference, 705.

11.   Kai Y Jair, Nikhil N Batra, Lidan You, Christopher R. Jacobs (2003) The Dynamics of F-actin cytoskeleton reorganization under loading-induced oscillatory fluid flow in MC3T3-E1 pre-osteoblasts. Transactions of the 2003 Summer Bioengineering Conference, 697.

12.   Lidan You (Invited speaker), Christopher R. Jacobs (2003) Proliferation rate regulation by oscillatory fluid flow in stem cells. The 50th Annual Meeting of American College of Sports Medicine, May 28-31, San Francisco, CA. Medicine and Science in Sports and Exercise 35(5): s4, 17.

13.   Lidan You, Christopher R. Jacobs (2005) Microfluidics system for the study on bone cell mechanotransduction. Transactions of the 51st Annual Meeting of the Orthopaedics Research Society 30, 146.

14.   Lidan You, SaraTemiyasathit, Peling Lee,  Chi Hyun Kim, Padmaja Tummala, Wei Yao, Wade Kingery, Christopher R. Jacobs (2006) Osteocytes as Mechanosensors in the inhibition of bone resorption due to mechanical loading. Transactions of the 52st Annual Meeting of the Orthopaedics Research Society 31: 0382.

15.   Lidan You, Sara Temiyasathit , Christopher R. Jacobs (2006) Osteocytes as Mechanosensors in the inhibition of bone resorption due to mechanical loading. The 5th World Congress of Biomechanics, Munich, German.

16.   Lidan You, Garcia, A.J. and Jacobs, C.R. (2007) “Using micropatterned surface to study bone cell mechanotransduction”. Biomedical Engineering Society 2007 Annual Fall Meeting, Los Angeles, CA., USA. September 26-29, 2007.

  1. Esther Lau, Qi-Ming Pang, Lidan You (2009) “Cellular and molecular mechanism underlying the anti resorptive effect of low-magnitude, high-frequency vibrations on bone” 55th Annual meeting of the Orthopaedic Research Society, Feb. 22-25, 2009. Las Vegas

18.   Wing-Yee Cheung, Chao Liu, Craig Simmons, Lidan You (2009) “Osteocyte Apoptosis is Flow-Regulated and Promotes Endothelial Cell Proliferation and Migration” 55th Annual meeting of the Orthopaedic Research Society, Feb. 22-25, 2009. Las Vegas. (Podium presentation, top 5% quality)

  1. Saja Al-Dujaili, Axel Guenther, Lidan You (2009)  “A Study of the Effect of Mechanical Loading on Osteocyte-Mediated Bone Remodeling in a Microfluidic Co-Culture System” 55th Annual meeting of the Orthopaedic Research Society, Feb. 22-25, 2009. Las Vegas (Short talk podium presentation, top 10% quality)
  • Yan Zhao, Linus H.C. Leung, Hani Naguib, Lidan You (2009)  “Microfluidics Chamber System for Bone Cell Mechanotransduction Study and Bone Tissue Engineering Application” 55th Annual meeting of the Orthopaedic Research Society, Feb. 22-25, 2009. Las Vegas.
  • Elizabeth Han, Yu Xue, Steffen-Sebastian Bolz, Scott Heximer, Craig A. Simmons, Lidan You (2009) “The Role of the Sphingosine-1-Phosphate Signaling Pathway in Osteocyte Mechanotransduction” 55th Annual meeting of the Orthopaedic Research Society, Feb. 22-25, 2009. Las Vegas.
  • Wing-Yee Cheung, Chao Liu, Craig Simmons, Lidan You (2009) “Osteocyte Apoptosis is Flow-Regulated and Promotes Endothelial Cell Proliferation, Migration and Tubule Network Formation” Biomedical Engineering Society 2009 meeting, Pittsburgh, Oct. 7-10, 2009.
  • Chao Liu, Lidan You (2009) “Effect of Cyclic Hydrostatic Pressure on Osteocytes” Biomedical Engineering Society 2009 meeting, Pittsburgh, Oct. 7-10, 2009.
  • Saja Al-Dujaili, Axel Guenther, Lidan You (2009)  “Microfluidic Co-Culture System for Studying the Effect of Mechanical Forces on Bone Remodeling” Biomedical Engineering Society 2009 meeting, Pittsburgh, Oct. 7-10, 2009.
  • Hui Lu, Esther Lau, Andrew Xiao, Lidan You, and Dawei Liu (2009) “Biological Responses of Cementoblasts to Mechanical Vibration in Vitro” American Association for Dental Research Annual Meeting, March 3-6, 2010, Washington, DC USA
  • Saja Al-Dujaili, Kyle Tsang, Lidan You (2010) “Apoptotic Osteocytes Directly and Indirectly Promote Osteoclast Formation” ORS 56th Annual Meeting, March 6-9, 2010 in New Orleans, Louisiana.
  • Emily Rose, Lidan You (2010) “Osteocytes differentially respond to different levels of shear stress” ORS 56th Annual Meeting, March 6-9, 2010 in New Orleans, Louisiana.
  • Esther Lau, Hong Lu, Dawei Liu, Lidan You (2010) “Low-magnitude, high-frequency vibration inhibits osteoclast formation via soluble factors from MLO-Y4 osteocytes” ORS 56th Annual Meeting, March 6-9, 2010 in New Orleans, Louisiana.
  • Esther Lau, Lidan You (2010) “Effect of low-magnitude, high-frequency vibration on the osteogenic differentiation of bone marrow stromal cells” ORS 56th Annual Meeting, March 6-9, 2010 in New Orleans, Louisiana.
  • Chao Liu, Ronak Gandhi, Liyun Wang, Lidan You (2010) “Effect of Cyclic Hydraulic Pressure on Osteocytes” ORS 56th Annual Meeting, March 6-9, 2010 in New Orleans, Louisiana.
  • Wing-Yee Chueng, Craig Simmons, Lidan You (2010) “TNF-alfa Induced Osteocyte Apoptosis Promotes Tubule Network Formation In Vitro Possibly Via VEGF” ORS 56th Annual Meeting, March 6-9, 2010 in New Orleans, Louisiana.
  • Zhe Lu, Christopher Moraes, Yan Zhao, Lidan You, Craig A. Simmons, and Yu Sun (2010) “A Micromanipulation System for Single Cell Deposition” IEEE Conf. Robotics and Automation, Anchorage, Alaska, USA. May 3 – 8, 2010. (847 selected out of 2062 submissions)
  • Robert Crawford, Girolama Bueti, Rungun Nathan, Lidan You, and Qianhong Wu (2010) “Permeability Measurements for Random Soft Porous Medium and its Implications to Lift Generation” Third International Conference on Porous Media and its Applications in Science, Engineering and Industry, Montecatini, Italy, June 20-25, 2010.
  • Lidan You (2010) (Invited speaker and the symposium chair) “Bone cell mechanobiology” 6th World Congress on Biomechanics, August 1-6, 2010, Singapore.
  • Saja Al-Dujaili, Lidan You, Axel Guenther (2010) “Microfluidic Fluid Shear Delivery System for In Vitro Osteocyte Mechanoregulation” 15th Canadian Aeronautics and Space Institute Astronautics conferences. Toronto, ON, Canada May 4-6, 2010
  • Chao Liu, Yan Zhao, Wing-Yee Cheung, Ronak Ghandi, Liyun Wang, Lidan You (2010) “Effect of Cyclic Hydraulic Pressure on Osteocytes” 16th Canadian Connective Tissue Conference. Toronto, ON, Canada. June 3-5, 2010.
  • Wing-Yee Cheung, Craig Simmons, Lidan You (2010) “Osteocyte apoptosis promotes angiogenesis and osteoclast precursor adhesion in vitro” 16th Canadian Connective Tissue Conference. Toronto, ON, Canada. June 3-5, 2010.
  • Esther Lau, Saja Al-Dujaili,Axel Guenther, Dawei Liu, Liyun Wang, Lidan You (2010) “ Effect of low magnitude high frequency vibration on osteocytes in the regulation of osteoclasts” 16th Canadian Connective Tissue Conference. Toronto, ON, Canada. June 3-5, 2010.
  • Rachel Tonelli-Zasarsky, Wing-Yee Cheung, Craig Simmons, Lidan You (2010) “An In Vitro Study of the Mechanism and Regulation of Fluid Flow Protection Against Osteocyte Apoptosis” 16th Canadian Connective Tissue Conference. Toronto, ON, Canada. June 3-5, 2010.
  • Jason Li, Emily Rose, Lidan You (2010) “Regulation of osteocyte gene expression by different mechanical stimuli” 16th Canadian Connective Tissue Conference. Toronto, ON, Canada. June 3-5, 2010.
  • Saja Al-Dujaili, Axel Guenther, Lidan You (2010) “Osteocytes directly and indirectly regulates osteoclast formation” 16th Canadian Connective Tissue Conference. Toronto, ON, Canada. June 3-5, 2010.
  • Robert Crawford, Girolama Bueti, Rungun Nathan, Lidan You, Qianhong Wu (2010) “Permeability Measurements for Random Soft Porous Medium and its Implications to Lift Generation”,3rd International Conference on Porous Media and its Applications in Science, Engineering and Industry Montecatini, ITALY, JUN 20-25, 2010. Porous Media and Its Applications in Science, Engineering and Industry. AIP Conference Proceedings    1254: 143-148, 2010.
  • Saja Al-Dujaili, Lidan You, Axel Guenther (2010) “Microfluidic fluid shear delivery system for in vitro bone mechanogulation” 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Groningen, Netherland, October 3-7, 2010
  • Johnny Zhang, Yan Zhao, Yu Xue, Elizabeth Han, Steffen-Sebastian Bolz, Lidan You (2010) “The Role of Sphingosine-1-Phosphate Signaling Pathway in Osteocyte Mechanotransduction” 2010 annual meeting of the American Society of Bone and Mineral Research. Toronto, ON, Canada. October 15-19, 2010.
  • Wing-Yee Cheung, Craig Simmons, Lidan You (2010) “Osteocyte apoptosis promotes angiogenesis and osteoclast precursor adhesion in vitro” 2010 annual meeting of the American Society of Bone and Mineral Research. Toronto, ON, Canada. October 15-19, 2010
  • Dina Badawy, Hani Naguib, Lidan You (2010) “Bio-composite Microfluidic Platforms for Bone Cell Mechanobiology Study” 2010 annual meeting of the American Society of Bone and Mineral Research. Toronto, ON, Canada. October 15-19, 2010.
  • Saja Al-Dujaili, Axel Guenther, Lidan You (2010) “Osteocytes directly and indirectly regulates osteoclast formation” 2010 annual meeting of the American Society of Bone and Mineral Research. Toronto, ON, Canada. October 15-19, 2010.
  • Jason Li, Emily Rose, Lidan You (2010) “Effect of variable oscillatory fluid flow conditions on osteocyte activity” 2010 annual meeting of the American Society of Bone and Mineral Research. Toronto, ON, Canada. October 15-19, 2010.
  • Chao Liu, Yan Zhao, Wing-Yee- Cheung, Ronak Gandhi, Liyun Wang, Lidan You (2010) “ Effects of cyclic hydraulic pressure on osteocytes” 2010 annual meeting of the American Society of Bone and Mineral Research. Toronto, ON, Canada. October 15-19, 2010
  • Wing-Yee Cheung, Craig Simmons, Lidan You (2011) “IL-6 and ICAM-1 Mediate Osteocyte Apoptosis-Induced Osteoclast Precursor Adhesion to Endothelium In Vitro” 2011 ORS 57th Annual Meeting, January 13-15, 2011, Long Beach, California, USA.
  • Jason Li, Emily Rose, Esther Lau, Yu Sun, Lidan You (2011) “Osteocytes differentially respond to different oscillatory fluid flow condition” 2011 ORS 57th Annual Meeting, January 13-15, 2011, Long Beach, California, USA.
  • Saja Al-Dujaili, Axel Guenther, Lidan You (2011) “Osteocyte Apoptosis Directly and Indirectly Promotes Osteoclast Formation In Vitro” 2011 ORS 57th Annual Meeting, January 13-15, 2011, Long Beach, California, USA.
  • Saja Al-Dujaili, Esther Lau, Axel Guenther, Lidan You (2011) “Apoptotic Osteocytes Promote In Vitro Osteoclastogenesis Directly through RANKL and Indirectly Through M-CSF and VEGF” 2011 American Society of Bone and Mineral Research Annual Meeting, September 16-20, 2011, San Diego, California, USA.
  • Chao Liu, Lidan You (2011) “Responses of Osteocytes to Microdamage in vitro” 2011 American Society of Bone and Mineral Research Annual Meeting, September 16-20, 2011, San Diego, California, USA.
  • Saja Al-Dujaili, Chao Liu, Axel Guenther, Lidan You (2012) “Osteocytes exhibit multiple calcium oscillations in response to mechanical loading” ORS 58th Annual Meeting, February 4-7, 2012, San Francisco, California, USA.
  • Jia Ning Zhang, Chao Liu, Lidan You (2012) “The Effect of Mechanical Stimulation on Osteocyte Chemo-Sensitivity” ORS 58th Annual Meeting, February 4-7, 2012, San Francisco, California, USA.
  • Dawei Liu, Chao Liu, Lidan You (2012) “Mechanical Vibration in Differential Responses in Osteocytes Verse Cementoblasts” 41st Annual Meeting & Exhibition of the American Association for Dental Research, March 21-24, Tempa, Florida, USA.
  • Wing-Yee Cheung, Craig Simmons, Lidan You (2012) “Effect of osteocyte apoptosis on osteoclast precursor recruitment” 18th Canadian Connective Tissue Conference, June 8-10, 2012. Toronto. (Podium)
  • Jia Ning Zhang, Chao Liu, Lidan You (2012) “The Effect of Mechanical Stimulation on Osteocyte Chemo-Sensitivity” 18th Canadian Connective Tissue Conference, June 8-10, 2012. Toronto. (Poster)
  • Saja Al-Dujaili, Chao Liu, Axel Guenther, Lidan You (2012) “Osteocytes exhibit multiple calcium oscillations in response to mechanical loading” 18th Canadian Connective Tissue Conference, June 8-10, 2012. Toronto. (Poster)
  • Chao Liu, Lidan You (2011) “In Vitro Investigation of Osteocyte Response to Microdamage” 18th Canadian Connective Tissue Conference, June 8-10, 2012. Toronto. (Poster)
  • Hashem Al-Dujaili, Christian Fischer, Saja Al-Dujaili, Lidan You (2013) “Apoptotic Osteocytes Promote Chondrocyte Apoptosis and Prevent Chondrogenesis via Soluble Factors” ORS 59th Annual Meeting, January 26-29, 2013, San Antonio, USA.  (Poster)
  • Chao Liu; Hashem Al-Dujaili, Christian Fischer; Liyun Wang, Lidan You (2013) “Altered Osteocyte Mechanosensitivity in Response to Elevated Extracellular Glucose Levels” ORS 59th Annual Meeting, January 26-29, 2013, San Antonio, USA.  (Poster)
  • Jia Ning Zhang, Chao Liu, Lidan You (2013) “The Effect of Mechanical Stimulation on Osteocyte Chemo-Sensitivity” ORS 59th Annual Meeting, January 26-29, 2013, San Antonio, USA.  (Poster)
  • Chao Liu, Hashem Al-Dujaili, Christian Fischer, Liyun Wang, Lidan You (2013) “Altered Osteocyte Mechanosensitivity in Response to Elevated Extracellular Glucose Levels” ASBMR 2013 Annual Meeting, October 4-7, 2013, Baltimore, USA. (Poster, UofT SGS conference grant)
  • Chao Liu, Xiaoqing Zhang, Michael Wu, Lidan You (2014) “Mechanical Regulation of Osteocyte Responses to Microdamage in vitro” 60th Annual meeting of ORS, March 15-18, 2014, New Orleans, USA. (Poster)
  • Chao Liu, Xiaoqing Zhang, Michael Wu, Lidan You (2014) “Mechanical Regulation of Osteocyte Responses to Microdamage in vitro” Canadian Society of Mechanical Engineering International Congress 2014, June 1-4, Toronto, Ontario, Canada. (Podium)
  • Kelvin Middleton, Lidan You (2014) “Development of a Microfluidic System to Investigate Bone Cell Signaling” Canadian Society of Mechanical Engineering International Congress 2014, June 1-4, Toronto, Ontario, Canada. (Podium)
  • Yu-Heng Vivian Ma, Lidan You (2014) “Conditioned Medium from Osteocyte-Like Cells Exposed to Mechanical Loading Attracts Breast Cancer Cells” Canadian Society of Mechanical Engineering International Congress 2014, June 1-4, Toronto, Ontario, Canada. (Podium)
  • Yu-Heng Vivian Ma, Chao Liu, Lidan You (2014) “Osteocytes’ Response to Mechanical Loading Supports Breast Cancer Cell Growth and Migration” 20th Canadian Connective Tissue Conference June 8-10, 2014, London, Ontario, Canada. (Poster)
  • Chao Liu, Xiaoqing Zhang, Michael Wu, Lidan You (2014) “Mechanical Regulation of Osteocyte Responses to Microdamage in vitro” 20th Canadian Connective Tissue Conference June 8-10, 2014, London, Ontario, Canada. (Poster)
  • Kelvin Middleton, Lidan You (2014) “Development of a Microfluidic System to Investigate Bone Cell Signaling” 20th Canadian Connective Tissue Conference June 8-10, 2014, London, Ontario, Canada. (Poster)
  • Kevin Middleton (Invited speaker), Xueting Mei, Lidan You (2014) “A Microfluidic System to Study the Effects of Mechanically Loaded Osteocytes on Osteoclast Migration and Differentiation” 12th International Bone Fluid Flow Workshop, September 10-11, 2014, Houston, Texas, Unites States. (Podium)
  • Chao Liu, Xiaoqing Zhang, Michael Wu, Lidan You (2014) “Microdamage and Mechanical Loading Have an Interactive Effect on Remodeling Signals Produced by Osteocyte” 12th International Bone Fluid Flow Workshop, September 10-11, 2014, Houston, Texas, Unites States. (Poster)
  • Yu-Heng Vivian Ma, Chao Liu, Peter Gao, Shreyash Dalmia, Lidan You (2014) “Osteocytes’ Response to Mechanical Loading Supports Breast Cancer Cell Growth and Migration” 12th International Bone Fluid Flow Workshop, September 10-11, 2014, Houston, Texas, Unites States. (Poster)
  • Kevin Middleton, Xueting Mei, Bin Deng, Wei Chao, Jian Chen, Junbo Wang, Lidan You (Invited Speaker, Scientific and organizing committee member) (2014) “Microfluidic platform for bone cell mechanobiology” 12th International Bone Fluid Flow Workshop, September 10-11, 2014, Houston, Texas, Unites States. (podium)
  • Yu-Heng Vivian Ma, Lidan You (2014) “Osteocytes’ Response to Mechanical Loading Supports Breast Cancer Cell Growth and Migration” Annual Meeting – American Society of Bone and Mineral Research, September 12-15, 2014, Houston, Texas, United States. (Poster)
  • Chao Liu, Xiaoqing Zhang, Michael Wu, Lidan You (2014) “Microdamage and Mechanical Loading Have an Interactive Effect on Remodeling Signals Produced by Osteocyte “Annual Meeting – American Society of Bone and Mineral Research, September 12-15, 2014, Houston, Texas, United States. (Poster)
  • Kelvin Middleton, Lidan You (2014) “A Microfluidic System to Study the Effects of Mechanically Loaded Osteocytes on Osteoclast Function” Annual Meeting – American Society of Bone and Mineral Research, September 12-15, 2014, Houston, Texas, United States. (Poster)
  • Yu-Heng Vivian Ma, Lidan You (2014) “Osteocytes’ Response to Mechanical Loading Supports Breast Cancer Cell Growth and Migration” Biomedical Engineering Society 2014 Annual Meeting, October 22-25, 2014, San Antonio, Texas, Unites States. (Poster)
  • Kelvin Middleton, Lidan You (2014) “A Microfluidic System to Study the Effects of Mechanically Loaded Osteocytes on Osteoclast Function” Biomedical Engineering Society 2014 Annual Meeting, October 22-25, 2014, San Antonio, Texas, Unites States. (Poster)
  • Chao Wei, Deyong Chen, Yuanchen Wei, Lidan You, Junbo Wang, and Jian Chen (2014) “On-Chip culture of Osteocytes” The 18th International Conference on  Miniaturized Systems for Chemistry and Life Sciences (microTAS 2014), October 26-30, San Antonio, Texas, United States. (Poster)
  • Kelvin Middleton, Lidan You (2014) “A Microfluidic System to Study the Effects of Mechanically Loaded Osteocytes on Osteoclast Function” The 18th International Conference on  Miniaturized Systems for Chemistry and Life Sciences (microTAS 2014), October 26-30, San Antonio, Texas, United States. (Poster)
  • Chao Liu, Frank Xi Sun, Lidan You (2015) “Mechanical Loading System to Apply Concurrent Physiological Pressure and Shear to Osteocytes” Orthopaedic Research Society 2015 Annual Meeting, March 28-31, Las Vegas, Nevada, Unites States. (Poster)
  • Chao Liu, Xiaoqing Zhang, Michael Wu, Lidan You (2015) “Microdamage and Mechanical Loading Have an Interactive Effect on Remodeling Signals Produced by Osteocyte” Orthopaedic Research Society 2015 Annual Meeting, March 28-31, Las Vegas, Nevada, Unites States. (Poster)
  • Avinash Kondiboyina, Kevin Middleton, Mike Borrett, Christina Mei, Lidan You (2015) “Analyzing the Effect of the Reynolds Number of Flow on Osteocytes” Orthopaedic Research Society 2015 Annual Meeting, March 28-31, Las Vegas, Nevada, Unites States. (Poster)
  • Kevin Middleton, Xueting Christina Mei, Lidan You (2015) “A Microfluidic System to Study the Osteocytes and Osteoclasts Communication on Bone Remodelling Process under Loading” Orthopaedic Research Society 2015 Annual Meeting, March 28-31, Las Vegas, Nevada, Unites States. (Poster)
  • Yu-Heng Vivian Ma,Peter Gao, Shreyash Dalmia,Chao Liu, Lidan You (2015) “Osteocytes’ Response to Mechanical Loading Supports Breast Cancer Cell Growth and Migration”  Orthopaedic Research Society 2015 Annual Meeting, March 28-31, Las Vegas, Nevada, Unites States. (Poster)
  • Cheryl Druchok, Lidan You, Gregory R. Wohl (2015) “Timing of Indomethacin Administration and the PGE2 Response of MLO-Y4 Cells to Fluid-Flow Induced Shear Stress” Emerging Research in Bone Health: Preventative and Maintenance Strategies, April 30, Catharines, Ontario, Canada. (Poster)
  • Kevin Middleton, Danny Cen, Xueting Mei, Lidan You (2015) “Microfluidic Co-Culture Device For Investigating Cell Interactions During Mechanical Stimulation”, Biomedical Engineering Society 2015 Annual Meeting, October 7-10, 2015, Tampa, Florida, Unites States. (Poster)
  • Cheryl Druchok, Lidan You, Gregory Wohl (2015) “Timing of Indomethacin Administration Causes Differential PGE2 Response in Fluid Shear Stress Stimulated MLO-Y4 Cell” American Society of Bone and Mineral Research 2015 Annual Meeting, Oct. 9-12, 2015, Seattle, Washington, United States. (Poster)
  • Kevin Middleton, Avinash Kondiboyina, Yi Cui, Michael Borret, Xueting Mei, Lidan You (2016) “Osteocyte are Sensitive to the Reynolds Number of Fluid Flow Given a Constant Fluid Shear Stress and Flow Rate” Orthopaedic Research Society Annual Meeting, March 5-8, 2016, Orlando, Florida, United States. (Poster)
  • Yu-Heng Ma, Shreyash Dalmia, Peter Gao, Jacob Young, Chao Liu, Lidan You (2016) “Osteocytes Response to Mechanical Loading Supports Cancer Cell Growth and Migration, but Reduces Osteoclasts Support of Cancer Cells” Orthopaedic Research Society Annual Meeting, March 5-8, 2016, Orlando, Florida, United States. (Poster)
  • Miranda M. Carleton, Madeleine Bareau, Lidan You (2016) “Investigating Effects of Diabetes and Diabetic Treatments on Mechanically Loaded Bone Cells” Orthopaedic Research Society Annual Meeting, March 5-8, 2016, Orlando, Florida, United States. (Poster)
  • Yu-Heng Ma, Lidan You (2016) “Osteocytes’ Response to Mechanical Loading Supports Cancer Cell Growth and Migration, but Reduces Osteoclasts’s Support of Cancer Cells”, 71st Canadian Orthopaedic Association (COA) Annual Meeting and 50th Canadian Operational Research Society (CORS) Annual Meeting, June 16-19, 2016 Quebec City, Quebec, Canada. (Podium)
  • Madeleine Bareau, Lidan You (2016) “Investigating Effects of Diabetes and Diabetic Treatments on Mechanically Loaded Bone Cells” 71st Canadian Orthopaedic Association (COA) Annual Meeting and 50th Canadian Operational Research Society (CORS) Annual Meeting, June 16-19, 2016 Quebec City, Quebec, Canada. (High Score Poster highlighted in President’s reception of the conference)
  • Cheryl Druchok, Lidan You, Gregory Wohl (2016) “Timing of Indomethacin Administration Causes Differential PGE2 Response in Fluid Shear Stress Stimulated MLO-Y4 Cell” 71st Canadian Orthopaedic Association (COA) Annual Meeting and 50th Canadian Operational Research Society (CORS) Annual Meeting, June 16-19, 2016 Quebec City, Quebec, Canada. (High Score Poster highlighted in President’s reception of the conference)
  • Liangcheng Henry Xu, Lidan You (2017) “Creating Novel High-Throughput Microfluidic Platform for Osteocyte Mechanotransduction Studies” Orthopaedic Research Society Annual Meeting, March 19-22, 2017, San Diego, California, United States. (Poster 1654)
  • KevinMiddleton, Dongsub Shim, Deepika Devadas, Yu-Heng Ma, Edmond Young, Lidan You (2017) “Microfluidic Platform to Investigate the Role of Osteocytes on the Mechanical Regulation of Bone Metastasis” Orthopaedic Research Society Annual Meeting, March 19-22, 2017, San Diego, California, United States. (Poster 1655)
  1. Yu-Heng Ma, Candy Lam, Shreyash Dalmia, Peter Gao, Jacob Young, Chao Liu, Kevin Middleton, Lidan You (2017) “Mechanical Regulation of Breast Cancer Bone Metastasis via Osteocytes” Orthopaedic Research Society Annual Meeting, March 19-22, 2017, San Diego, California, United States. (Poster 1650)
  1. Jiachen Zhang, Onaizah Onaizah, Kevin Middleton, Lidan You, Eric D. Diller (2017) “Robust Grasping of Three-Dimensional Untethered Mobile Magnetic Microgripper for Autonomous Pick-and-Place Tasks the 2017 IEEE International Conference on Robotics and Automation, May 29 – June 3, 2017, Singapore.
  1. Liangcheng Xu, Lilia Fuller-Thomson, Lidan You (2018) “Novel in vitro Microfluidic Platforms for Osteocyte Mechanotransduction Studies” 2018 American Society of Bone and Mineral Research Annual Meeting, Sep. 28-Oct. 1, 2018, Montreal, Canada.
  1. Xueting Mei, Kevin Middleton, Yu-Heng Ma, Liangcheng Xu, Noosheen Walji, Edmond Young, Lidan You (2018) “Microfluidic Platform for Investigation of Mechanoregulation of Breast Cancer Bone Metastasis” 2018 American Society of Bone and Mineral Research Annual Meeting, Sep. 28-Oct. 1, 2018, Montreal, Canada.
  1. Yu-Heng Vivian Ma, Liangcheng Xu, Xueting Mei, Lidan You (2018) “Mechanical Regulation of Breast Cancer Bone Metastasis via Osteocytes’ Signaling to Endothelial Cells” 2018 American Society of Bone and Mineral Research Annual Meeting, Sep. 28-Oct. 1, 2018, Montreal, Canada.
  1. Xueting Mei, Kevin Middleton, Qianqian Wan, Dongsub Shim, Liangcheng Xu, Yu-Heng Ma, Deepica Devadas, Noosheen Walji, Edmond Young, Lidan You (2019) “Microfluidic Platform for Investigation of Mechanoregulation of Breast Cancer Bone Metastasis” 2019 Orthopaedic Research Society Annual Meeting, Paper No. 0082. Feb. 2-5, 2019, Austin, USA.
  1. Yu-Heng Vivian Ma, Liangcheng Xu, Xueting Mei, Lidan You (2019) “Mechanically stimulated osteocytes reduce the bone-metastatic potential of breast cancer cells in vitro by signalling through endothelial cells” 2019 Orthopaedic Research Society Annual Meeting, Paper No. 0111. Feb. 2-5, 2019, Austin, USA.
  1. Liangcheng Henry Xu, Han Shao, Lidan You (2019) “Bone Cell Mechanotransduction via OCY454 Osteocytes” 2019 Orthopaedic Research Society Annual Meeting, Paper No. 0246. Feb. 2-5, 2019, Austin, USA.
  1. Lidan You (2019) “Bone Cell Cross Talk Under Mechanical Loading” Canadian Connective Tissue Society 25th Annual Meeting, May 29-31, 2019, Montreal.
  1. Lidan You (2019) “Bone Mechanobiology-On-a-Chip” 7th Sino-American Workshop on Biomedical Engineering and Biomechanics, July 21-25, 2019, Chongqing, China.
  1. Dongfang Ouyang, Bin Tang, Wenqi He, Weicong Lin, Jaewon Park, Lidan You (2019) “An innovative microfluidic device to diagnosis Multiple Myeloma by mechanically capturing Circulating Clonal Plasma Cells in peripheral blood” 2019 Guangdong Blood Purification Annual Conference July 26-28,  Guangzhou, Guangdong, China.
  1. Dongfang Ouyang, Bin Tang, Wenqi He, Weicong Lin, Jaewon Park, Lidan You (2019) “An innovative microfluidic device to diagnosis Multiple Myeloma by mechanically capturing Circulating Clonal Plasma Cells in peripheral blood”  The 4th International Chinese Musculoskeletal Research Conference (ICMRC-2019) Aug. 9-12, 2019, Shenzhen, Guangdong, China
  1. Lidan You (2019) “Bone Cell Cross Talk Under Mechanical Loading” 16th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering and the 4th Conference on Imaging and Visualization, Paper 812, Aug. 14-16, 2019, New York, USA.
  1. Dongfang Ouyang, Yonghua Li, Jaewon Park, Bin Tang, Lidan You (2019) “Mechanical Segregation and Capturing of Clonal Circulating Plasma Cells In Multiple Myeloma Using Micropillar-Integrated Microfluidic Device” 2019 Biomedical Engineering Society Annual Meeting, Poster #1379. Oct. 16-19, 2019, Philadelphia, United States.
  1. Jeremy Saget, Marco Montoya, Ariel Seebarran, Pouya Ahmadian, Raem Naveed, Lidan You (2019) “Development of a lower body negative pressure sleeping bag for use in long duration spaceflight” The 70th International Astronautical Congress 2019, 21-25 October 2019, Washington D.C., United States
  1. Shubo Wang, Shaopeng Pei, Jerahme Martinez, Lidan You, Liyun Wang (2020) “In vivo effects of treadmill running and unilateral tibial loading on breast cancer induced osteolytic lesions in bone” 2020 Orthopaedic Research Society Annual Meeting, Feb. 8-11, 2020, Phoenix, USA. (Podium)
  1. Liangcheng Henry Xu, Xin Song, Gwennyth Carroll, Rafi Bienenstock, Dustin Yang, Lidan You (2020) “Novel in vitro Microfluidic Co-culture Platforms for Osteocyte Mechanotransduction Studies” 2020 Orthopaedic Research Society Annual Meeting, Feb. 8-11, 2020, Phoenix, USA. Feb. 8, paper #42 (Podium)
  1. Shubo Wang; Shaopeng Pei; Jerahme Martinez; Lidan You; Liyun Wang (2020) “In Vivo Effects Of Treadmill Running And Unilateral Tibial Loading On Breast Cancer Induced Osteolytic Lesions In Bone” 2020 Orthopaedic Research Society Annual Meeting, Feb. 8-11, 2020, Phoenix, USA. Feb. 8, paper #412 (Podium)

2.3   Books, Chapters in Books, UTMIE Series, Review Articles, and Non‑Technical Articles (trainee names underlined)

  1. Lidan You, Christopher R. Jacobs (2005) Cellular mechanotransduction. In: Nanoscale Technology in Biological Systems, CRC Press.
  • Chao Liu, Kevin Middleton, Lidan You (2015) Bone cell mechanobiology study on microfluidic platform. In: Integrative Mechanobiology: Micro- and Nano- Techniques in Cell Mechanobiology, Cambridge University Press. Pp 245-265.
  • Jason Li, Steve To, Lidan You, Yu Sun. (2016) Nanostructure Field Effect Transistor Biosensors. In: Encyclopedia of Nanotechnology, Page: 49-77 Springer.
  • Kevin Middleton, Yu-Heng Ma, Lidan You (2017) Bone Cell Response to Fluid Shear Stress and Hydrostatic/dynamic Pressure. In: Experimental Methods for Orthopaedic Biomechanics. Page: 217-232. Elsevier.

2.4   Patents

        Patent:  S05-175 “Microfluidic Bone Cell Chamber” filed January 26, 2006

IP Disclosure:

“Microfluidic Fluid Shear Delivery System for In Vitro Osteocyte Mechanoregulation” Saja Al-Dujaili, Lidan You, Axel Guenther. RIS #10002060. Filed on March 24th, 2010.

Section 3 – Professional Activities

  • Professional Association Memberships
Date Association
1999-present BMES:  Biomedical Engineering Society
1999- present ASME:  American Society of Mechanical Engineers
2005- present SPRBM:  Society for Physical Regulation in Biology and Medicine
2007- present ICMRS: International Chinese Musculoskeletal Research Society
2007- present CSME:  Canadian Society for Mechanical Engineering
2008- present ORS:  Orthopaedic Research Society
2009- present PEO: Professional Engineering Ontario
2010- present ASBMR: American Society of Bone and Mineral Research
2010- present CAN: Canadian Arthritis Network
2012- present TMC: Toronto Musculoskeletal Centre
2014- present OSCI: Ontario Stem Cell Institute
  • 3.2   Peer Review

Scientific Journal Articles

  • Acta Biomaterialia
  • Aging Clinical and Experimental Research
  • Annals of Biomedical Engineering
  • Biomechanics and Modeling in Mechanobiology
  • Biorheology
  • BMC Cancer
  • Bone
  • Bone Research
  • Cell Biology International
  • Cell Tissue Organ
  • Cellular and Molecular Bioengineering
  • Clinical Biomechanics
  • Connective Tissue Research
  • Experimental Cell Research
  • FASEB
  • Future Rheumatology
  • International Journal of Engineering
  • Journal of Biomechanics
  • Journal of Biomechanical Engineering
  • Journal of Orthopaedic Research
  • Journal of the Royal Society Interface
  • Lab on a Chip
  • Microfluidics and Nanofluidics
  • Molecular and Cellular Biochemistry
  • PLoS
  • PNAS
  • Regenerative Medicine
  • Redox

Grant Application

  • Panel member: NIH SBSR group, June 16-17, 2016, February 9-10, 2017
  • Panel member: CIHR BME committee 2018, 2019
  • Panel member: Arthritis Society’s Strategic Operating Grant (SOG) competition, 2019
  • External reviewer of Chinse Society of Theoretical and Applied Mechanics (CSTAM) Chinese Mechanics Prize Program
  • External reviewer of National Science Foundation (NSF) International Research Fellowship Program
  • External reviewer of University of Toronto Faculty of Dentistry Research Grant Program
  • External reviewer of University Health Network Animal Care committee
  • External reviewer of National Sciences and Engineering Research Council of Canada (NSERC) Discovery Program
  • External reviewer of NSERC Strategic Program
  • External reviewer of PSC-CUNY (City University of New York) Research Award Program
  • External reviewer of Villanova University Summer Research Support Grant
  • External reviewer of Wellcome Trust Fund, Physiological Science Research Grant Program
  • External reviewer of IC-IMPACTS Centres of Excellence Program
  • External Reviewer of Breast Cancer Now (UK)
  • External Reviewer of Breast Cancer Foundation New Zealand
  • Conference Papers/Awards
  • 2009 Canadian Medical and Biological Engineering conference abstracts review
  • 2010 International Chinese Hard Tissue Society Young Investigator Award Program

Peer Review -Textbook

  • Textbook “An Introduction to Cell Mechanics and Mechanobiology” by Christopher R. Jacobs

3.3        Professional Interests

  • Cancer bone metastasis
  • Bone biomechanics
  • Cell mechanobiology
  • Osteoporosis
  • Cell mechanics
  • Bone remodelling
  • Microfluidic platform design for cell mechanobiology study
  • CTC and CPC

3.4        Scholarly Addresses and Conference Presentations (presenter underlined, trainees in italic)

1.     Lidan You, Stephen C. Cowin, Sheldon Weinbaum (1999) Strain Amplification in the Bone Mechanosensory System. 1999 PreORS Meeting in Nanheim, California. Seventh Annual Symposium on Computational Methods in Orthopaedic Biomechanics, 1999, 12. (Podium)

2.     Lidan You, Stephen C. Cowin, Sheldon Weinbaum (1999) Strain Amplification in the Bone Mechanosensory System. 1999 International Mechanical Engineering Congress & Exposition in Nashville, Tennessee. The Proceedings of the 1999 International Mechanical Engineering Congress and Exposition, Bed-Vol. 43. (Poster)

3.     Lidan You, Stephen C. Cowin, Sheldon Weinbaum (1999) Strain Amplification in the Bone Mechanosensory System. The 1st  Joint BMES/EMBS Conference, Oct. 13-16, Atlanta, GA Proceedings of The First Joint BMES/EMBS conference 1999, 492. (Poster)

4.     Lidan You, Stephen C. Cowin, Mitchell B. Schaffler, Sheldon Weinbaum (2000) A Potential Mechanism for Mechanotransduction in Bone: Fluid flow Induced Strain Amplification on Bone Cells. The 2nd International Bone Fluid Flow Workshop, Sept. 20, New York, NY. (Poster)

5.     Lidan You, Stephen C. Cowin, Mitchell B. Schaffler, Sheldon Weinbaum (2000) Strain amplification in bone. Biomedical Engineering Society 2000 Annual Fall Meeting, Oct. 12-14, Seattle, Washington. Annals of Biomedical Engineering, 28 (Suppl. 1): S-6. (Podium)

6.     Lidan You, Stephen C. Cowin, Mitchell B. Schaffler, Sheldon Weinbaum (2001) Fluid flow induced strain amplification in bone cells. Transaction of the 47th Annual Meeting of Orthopaedic Research Society. 26, 563. (Poster)

7.     Lidan You, Stephen C. Cowin, Mitchell B. Schaffler, Sheldon Weinbaum (2001) Fluid flow induced strain amplification in bone cells. 31st  International Sun Valley Hard Tissue Workshop, Aug. 6-10, Sun Valley, Idaho. (Poster)

8.     Sheldon Weinbaum, Peng Guo and Lidan You (2002) Mechanotransduction and strain amplification in cells with microvilli and cell processes.  The 4th International Bone Fluid Flow Workshop, May 6-7, Amsterdam, Netherlands. (Poster)

9.     Lidan You, Sheldon Weinbaum, Stephen C. Cowin, Mitchell B. Schaffler (2002) Ultrastructure of osteocyte process. The 24th Annual Meeting of the American Society for Bone and Mineral Research in San Antonio, TX.  Journal of Bone and Mineral Research, 17 (Suppl 1): s352. (Poster)

10.   Lidan You, Sheldon Weinbaum, Stephen C. Cowin, Mitchell B. Schaffler (2002) A New Understanding of Osteocyte Process Ultrastructure. The  24th Annual International Conference of the EMBS and Annual Fall Meeting of the BMES, Proceedings of the Second Joint EMBS/BMES Conference Houston, TX, USA. Page 589, paper 117. (Podium)

11.   Lidan You (invited speaker), Sheldon Weinbaum, Stephen C. Cowin, Mitchell B. Schaffler (2003) Ultrastructure of Osteocyte Process. 2003 Symposium on the Mechanics of Physicochemical and Electromechanical Interactions in Porous Media, May 18-23, Rolduc, Kerkrade, Netherlands. (Podium)

12.   Lidan You (invited speaker), Christopher R. Jacobs (2003) Proliferation rate regulation by oscillatory fluid flow in stem cells. The 50th Annual Meeting of American College of Sports Medicine, May 28-31, San Francisco, CA. Medicine and Science in Sports and Exercise 35(5): s4, 17. (Podium)

13.   Kai Y Jair, Nikhil N Batra, Lidan You, Christopher R. Jacobs (2003) The Dynamics of F-actin cytoskeleton reorganization under loading-induced oscillatory fluid flow in MC3T3-E1 pre-osteoblasts. Transactions of the 2003 Summer Bioengineering Conference, 697. (Poster)

14.   Nikhil N Batra, Ying J. Li, Clare E. Yellowley, Lidan You, Christopher R. Jacobs (2003) Short term recovery periods lead to multiple oscillatory fluid flow induced intracellular calcium oscillations in osteoblastic cells. Transactions of the 2003 Summer Bioengineering Conference, 705. (Podium)

15.   Lidan You, Ying J. Li, Nikhil N Batra, Christopher R. Jacobs (2003) Design of a 3D microfluidics system for loading fluid flow on osteocyte process in vitro. Transactions of the 2003 Summer Bioengineering Conference, 695. (Podium)

16.   Lidan You, Ying J. Li, Nikhil N Batra, Christopher R. Jacobs (2003) The effect of oscillatory fluid flow on human marrow stromal cell proliferation. Transactions of the 2003 Summer Bioengineering Conference, 267. (Podium)

17.   Lidan You, Sheldon Weinbaum, Stephen C. Cowin, Mitchell B. Schaffler (2003) Ultrastructure of osteocyte process. The 5th International Bone Fluid Flow Workshop, March 16-17, Cleveland, OH. (Podium)

18.   Lidan You, Ying J. Li, Nikhil N Batra, Christopher R. Jacobs (2004) Effect of loading induced oscillatory fluid flow on human marrow stromal cell proliferation and differentiation . 2004 NASA Cell Science Conference, Feb. 26-28, Palo Alto, CA. (Podium)

19.   Lidan You, Christopher R. Jacobs (2004) Microchannel system for in vitro study on bone cell. The 6th International Bone Fluid Flow Workshop, Sept. 30-Oct. 1, Seattle, WA. (Podium)

20.   Lidan You, Christopher R. Jacobs (2004) Microfluidics system for the study on bone cell mechanotransduction. The 3rd Annual California Tissue Engineering Meeting, Palo Alto, CA. (Poster)

21.   Lidan You, Christopher R. Jacobs (2005) Microchannel system for in vitro study on bone cell. The 23rd Scientific Conference of the Society for Physical Regulation in Biology and Medicine, Jan. 12-14, Lake Tahoe, CA. (Podium)

22.   Lidan You, Christopher R. Jacobs (2005) Microfluidics system for the study on bone cell mechanotransduction. Transactions of the 51st Annual Meeting of the Orthopaedics Research Society 30, 146. (Podium)

23.   Lidan You, Sara Temiyasathit, and Christopher R. Jacobs (2006) Osteocytes ad Mechanosensors in the inhibition of bone resorption due to mechanical loading. The 24th  Scientific Conference of the Society for Physical Regulation in Biology and Medicine, Jan. 11-13, Cancun, Mexico.  (Podium)

24.   Lidan You, SaraTemiyasathit, Peling Lee,  Chi Hyun Kim, Padmaja Tummala, Wei Yao, Wade Kingery, Christopher R. Jacobs (2006) Osteocytes as Mechanosensors in the inhibition of bone resorption due to mechanical loading. Transactions of the 52st Annual Meeting of the Orthopaedics Research Society 31: 0382. (Poster)

25.   Lidan You, Sara Temiyasathit , Christopher R. Jacobs (2006) Osteocytes as Mechanosensors in the inhibition of bone resorption due to mechanical loading. The 5th World Congress of Biomechanics, Munich, German. (Podium)

27.   Lidan You (2007) “Mechanotransduction in Bone: Cellular Mechanism” Department of Bioengineering, Beijing University of Aeronautics and Astronautics, Beijing, China, May 17th, 2007 (Podium)

28.   Lidan You (2007) “Mechanotransduction in Bone: Cellular Mechanism” Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China, May 18th, 2007 (Podium)

  • Lidan You (2007) “Mechanotransduction in Bone: Cellular Mechanism” National Microgravity Laboratory and Center for Biomechanics and Bioengineering, Institute of Mechanics, Chinese Academy of Sciences, May 18th, 2007 (Podium)
  • Lidan You (2007) “Microsystems to study the bone cell mechanotransduction” Ontario-On-A-Chip Forum, Toronto, June 7th, 2007 (Podium)
  • Lidan You, Christopher Jacobs (2007) “Using micropatterned surface study the role of focal adhesion contact area in bone cell mechanotransduction” 8th International Bone Fluid Flow Workshop, New York, USA. September 13-14, 2007 (Podium)
  • Lidan You, Christopher Jacobs (2007) “Using Micropatterned Surface to Study Bone Cell Mechanotransduction” Annual Fall Meeting of Biomedical Engineering Society, September 26-29, Los Angeles. (Poster)
  • Esther Lau, Qi-Ming Pang, Lidan You (2009) “Cellular and molecular mechanism underlying the antiresorptive effect of low-magnitude, high-frequency vibrations on bone” 55th Annual meeting of the Orthopaedic Research Society, Feb. 22-25, 2009 (Poster)
  • Wing-Yee Cheung, Chao Liu, Craig Simmons, Lidan You (2009) “Osteocyte Apoptosis is Flow-Regulated and Promotes Endothelial Cell Proliferation and Migration” 55th Annual meeting of the Orthopaedic Research Society, Feb. 22-25, 2009. (Podium)
  • Saja Al-Dujaili, Axel Guenther, Lidan You (2009)  “A Study of the Effect of Mechanical Loading on Osteocyte-Mediated Bone Remodeling in a Microfluidic Co-Culture System” 55th Annual meeting of the Orthopaedic Research Society, Feb. 22-25, 2009. (Podium)
  • Yan Zhao, Linus H.C. Leung, Hani Naguib, Lidan You (2009)  “Microfluidics Chamber System for Bone Cell Mechanotransduction Study and Bone Tissue Engineering Application” 55th Annual meeting of the Orthopaedic Research Society, Feb. 22-25, 2009 (Poster)
  • Yan Zhao, Elizabeth Han, Yu Xue, Steffen-Sebastian Bolz, Scott Heximer, Craig A. Simmons, Lidan You (2009) “The Role of the Sphingosine-1-Phosphate Signaling Pathway in Osteocyte Mechanotransduction” 55th Annual meeting of the Orthopaedic Research Society, Feb. 22-25, 2009. (Poster)
  • Esther Lau; Andrew Xiao; Hong Lu; Lidan You; Dawei Liu (2009) “Effects of Low Magnitude High Frequency Mechanical Vibration on Cementoblasts In Vitro” 39th International Sun Valley Hard Tissue Workshop, Aug. 9-12, 2009, Sun Valley, Idaho. (Poster)
  • Lidan You (2009)  “Mechanical Regulation of cells that regulate bone” (Invited Speaker)  Department of Biomedical Engineering, City University of New York. June 10th, 2009.
  • Lidan You (2009)  “Mechanical Regulation of bone cells” (Invited talk)  Department of Biomedical Engineering, Columbus University, June 11th, 2009.
  • Wing-Yee Cheung, Chao Liu, Craig Simmons, Lidan You (2009) “Osteocyte Apoptosis is Flow-Regulated and Promotes Endothelial Cell Proliferation, Migration and Tubule Network Formation” Biomedical Engineering Society 2009 meeting, Pittsburgh, Oct. 7-10, 2009. (Podium, BMES Student Travel Award)
  • Chao Liu, Lidan You (2009) “Effect of Cyclic Hydrostatic Pressure on Osteocytes” Biomedical Engineering Society 2009 meeting, Pittsburgh, Oct. 7-10, 2009. (Podium, BMES Student Travel Award)
  • Saja Al-Dujaili, Axel Guenther, Lidan You (2009) “Microfluidic Co-Culture System for Studying the Effect of Mechanical Forces on Bone Remodeling” Biomedical Engineering Society 2009 meeting, Pittsburgh, Oct. 7-10, 2009.  (Poster)
  • Wing-Yee Cheung, Chao Liu, Craig Simmons, Lidan You (2009) “Osteocyte Apoptosis is Flow-Regulated and Promotes Angiogenesis In Vitro” 10th International Bone Fluid Flow Workshop, Penn State Hershey, Pennsylvania, Sep. 16-17, 2009. (Podium)
  • Chao Liu, Lidan You (2009) “Effect of Cyclic Hydrostatic Pressure on Osteocytes” 10th International Bone Fluid Flow Workshop, Penn State Hershey, Pennsylvania, Sep. 16-17, 2009. (Podium)
  • Saja Al-Dujaili, Axel Guenther, Lidan You (2009) “Microfluidic Co-Culture System for Studying the Effect of Mechanical Forces on Bone Remodeling” 10th International Bone Fluid Flow Workshop, Penn State Hershey, Pennsylvania, Sep. 16-17, 2009. (Podium)
  • Lidan You (2009) “Cellular Biomechanics” Canadian Institutes of Health Research (CIHR) Institute of Genetics (IG) and Institute of Musculoskeletal Health and Arthritis (IMHA) Eighth Annual New Principal Investigators Meeting,  Jackson’s Point, Ontario, Canada, November 6-8, 2009. (Podium)
  • Hui Lu, Esther Lau, Andrew Xiao, Lidan You, and Dawei Liu (2010) “Biological Responses of Cementoblasts to Mechanical Vibration in Vitro” American Association for Dental Research Annual Meeting, March 3-6, 2010, Washington, DC US (Poster)
  • Saja Al-Dujaili, Kyle Tsang, Lidan You (2010) “Apoptotic Osteocytes Directly and Indirectly Promote Osteoclast Formation” ORS 56th Annual Meeting, March 6-9, 2010 in New Orleans, Louisiana. (Poster, CIHR-IMHA Travel Award)
  • Emily Rose, Lidan You (2010) “Osteocytes differentially respond to different levels of shear stress” ORS 56th Annual Meeting, March 6-9, 2010 in New Orleans, Louisiana. (Poster)
  • Esther Lau, Hong Lu, Dawei Liu, Lidan You (2010) “Low-magnitude, high-frequency vibration inhibits osteoclast formation via soluble factors from MLO-Y4 osteocytes” ORS 56th Annual Meeting, March 6-9, 2010 in New Orleans, Louisiana. (Podium, CIHR-IMHA Travel Award)
  • Esther Lau, Lidan You (2010) “Effect of low-magnitude, high-frequency vibration on the osteogenic differentiation of bone marrow stromal cells” ORS 56th Annual Meeting, March 6-9, 2010 in New Orleans, Louisiana. (Poster)
  • Chao Liu, Ronak Gandhi, Liyun Wang, Lidan You (2010) “Effect of Cyclic Hydraulic Pressure on Osteocytes” ORS 56th Annual Meeting, March 6-9, 2010 in New Orleans, Louisiana. (Poster, CIHR-IMHA Travel Award)
  • Wing-Yee Cheung, Craig Simmons, Lidan You (2010) “TNF-alfa Induced Osteocyte Apoptosis Promotes Tubule Network Formation In Vitro Possibly Via VEGF” ORS 56th Annual Meeting, March 6-9, 2010 in New Orleans, Louisiana (Podium, CIHR-IMHA Travel Award).
  • Zhe Lu, Christopher Moraes, Yan Zhao, Lidan You, Craig A. Simmons, and Yu Sun (2010) “A Micromanipulation System for Single Cell Deposition” IEEE Conf. Robotics and Automation, Anchorage, Alaska, USA. May 3 – 8, 2010. (847 selected from 2062 submissions, Poster, Best Manipulation Paper Award finalist)
  • Saja Al-Dujaili, Lidan You, Axel Guenther (2010) “Microfluidic Fluid Shear Delivery System for In Vitro Osteocyte Mechanoregulation” 15th Canadian Aeronautics and Space Institute Astronautics conferences. Toronto, ON, Canada May 4-6, 2010 (Podium)
  • Chao Liu, Yan Zhao, Wing-Yee Cheung, Ronak Ghandi, Liyun Wang, Lidan You (2010) “Effect of Cyclic Hydraulic Pressure on Osteocytes” 16th Canadian Connective Tissue Conference. Toronto, ON, Canada. June 3-5, 2010 (Podium).
  • Wing-Yee Cheung, Craig Simmons, Lidan You (2010) “Osteocyte apoptosis promotes angiogenesis and osteoclast precursor adhesion in vitro” 16th Canadian Connective Tissue Conference. Toronto, ON, Canada. June 3-5, 2010 (Poster).
  • Esther Lau, Saja Al-Dujaili, Axel Guenther, Dawei Liu, Liyun Wang, Lidan You (2010) “ Effect of low magnitude high frequency vibration on osteocytes in the regulation of osteoclasts” 16th Canadian Connective Tissue Conference. Toronto, ON, Canada. June 3-5, 2010 (Poster).
  • Rachel Tonelli-Zasarsky, Wing-Yee Cheung, Craig Simmons, Lidan You (2010) “An In Vitro Study of the Mechanism and Regulation of Fluid Flow Protection Against Osteocyte Apoptosis” 16th Canadian Connective Tissue Conference. Toronto, ON, Canada. June 3-5, 2010 (Poster).
  • Jason Li, Emily Rose, Lidan You (2010) “Regulation of osteocyte gene expression by different mechanical stimuli” 16th Canadian Connective Tissue Conference. Toronto, ON, Canada. June 3-5, 2010 (Poster).
  • Saja Al-Dujaili, Axel Guenther, Lidan You (2010) “Osteocytes directly and indirectly regulates osteoclast formation” 16th Canadian Connective Tissue Conference. Toronto, ON, Canada. June 3-5, 2010 (Poster).
  • Robert Crawford, Girolama Bueti, Rungun Nathan, Lidan You, Qianhong Wu (2010) “Permeability Measurements for Random Soft Porous Medium and its Implications to Lift Generation”,3rd International Conference on Porous Media and its Applications in Science, Engineering and Industry Montecatini, ITALY, JUN 20-25, 2010. Porous Media and Its Applications in Science, Engineering and Industry. AIP Conference Proceedings    1254: 143-148, 2010. (Podium)
  • Saja Al-Dujaili, Lidan You, Axel Guenther (2010) “Microfluidic fluid shear delivery system for in vitro bone mechanogulation” 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Groningen, Netherland, October 3-7, 2010 (Poster, MATCH travel grant).
  • Wing-Yee Cheung, Craig Simmons, Lidan You (2010) “Osteocyte apoptosis promotes angiogenesis and osteoclast precursor adhesion in vitro” 11th International Bone Fluid Flow Workshop, Toronto, ON, Canada. October 13-14, 2010 (Poster).
  • Johnny Zhang, Yan Zhao, Yu Xue, Elizabeth Han, Steffen-Sebastian Bolz, Lidan You (2010) “The Role of Sphingosine-1-Phosphate Signaling Pathway in Osteocyte Mechanotransduction” 11th International Bone Fluid Flow Workshop, Toronto, ON, Canada. October 13-14, 2010 (Podium, Student Paper Award).
  • Dina Badawy, Hani Naguib, Lidan You (2010) “Bio-composite Microfluidic Platforms for Bone Cell Mechanobiology Study” 11th International Bone Fluid Flow Workshop, Toronto, ON, Canada. October 13-14, 2010 (Poster).
  • Jason Li, Emily Rose, Lidan You (2010) “Effect of variable oscillatory fluid flow conditions on osteocyte activity” 11th International Bone Fluid Flow Workshop, Toronto, ON, Canada. October 13-14, 2010 (Poster, Student Paper Award).
  • Chao Liu, Yan Zhao, Wing-Yee- Cheung, Ronak Gandhi, Liyun Wang, Lidan You (2010) “ Effects of cyclic hydraulic pressure on osteocytes” 11th International Bone Fluid Flow Workshop, Toronto, ON, Canada. October 13-14, 2010 (Poster)
  • Saja Al-Dujaili, Axel Guenther, Lidan You (2010) “Osteocytes directly and indirectly regulates osteoclast formation” 11th International Bone Fluid Flow Workshop, Toronto, ON, Canada. October 13-14, 2010 (Poster, Best Poster Award)
  • Johnny Zhang, Yan Zhao, Yu Xue, Elizabeth Han, Steffen-Sebastian Bolz, Lidan You (2010) “The Role of Sphingosine-1-Phosphate Signaling Pathway in Osteocyte Mechanotransduction” 2010 annual meeting of the American Society of Bone and Mineral Research. Toronto, ON, Canada. October 15-19, 2010 (Poster, President’s Poster Competition finalist).
  • Wing-Yee Cheung, Craig Simmons, Lidan You (2010) “Osteocyte apoptosis promotes angiogenesis and osteoclast precursor adhesion in vitro” 2010 annual meeting of the American Society of Bone and Mineral Research. Toronto, ON, Canada. October 15-19, 2010 (Podium, Young Investigator Travel Grant)
  • Dina Badawy, Hani Naguib, Lidan You (2010) “Bio-composite Microfluidic Platforms for Bone Cell Mechanobiology Study” 2010 annual meeting of the American Society of Bone and Mineral Research. Toronto, ON, Canada. October 15-19, 2010 (Poster).
  • Saja Al-Dujaili, Axel Guenther, Lidan You (2010) “Osteocytes directly and indirectly regulates osteoclast formation” 2010 annual meeting of the American Society of Bone and Mineral Research. Toronto, ON, Canada. October 15-19, 2010 (Poster).
  • Jason Li, Emily Rose, Lidan You (2010) “Effect of variable oscillatory fluid flow conditions on osteocyte activity” 2010 annual meeting of the American Society of Bone and Mineral Research. Toronto, ON, Canada. October 15-19, 2010 (Poster).
  • Chao Liu, Yan Zhao, Wing-Yee- Cheung, Ronak Gandhi, Liyun Wang, Lidan You (2010) “ Effects of cyclic hydraulic pressure on osteocytes” 2010 annual meeting of the American Society of Bone and Mineral Research. Toronto, ON, Canada. October 15-19, 2010 (Poster).
  • Wing-Yee Cheung, Craig Simmons, Lidan You (2011) “IL-6 and ICAM-1 Mediate Osteocyte Apoptosis-Induced Osteoclast Precursor Adhesion to Endothelium In Vitro” 2011 ORS 57th Annual Meeting, January 13-15, 2011, Long Beach, California, USA. (Podium)
  • Jason Li , Emily Rose, Esther Lau, Yu Sun, Lidan You (2011) “Osteocytes differentially respond to different oscillatory fluid flow condition” 2011 ORS 57th Annual Meeting, January 13-15, 2011, Long Beach, California, USA. (Podium, CIHR-IMHA Travel Award)
  • Saja Al-Dujaili, Axel Guenther, Lidan You (2011) “Osteocyte Apoptosis Directly and Indirectly Promotes Osteoclast Formation In Vitro” 2011 ORS 57th Annual Meeting, January 13-15, 2011, Long Beach, California, USA. (Poster)
  • Saja Al-Dujaili, Esther Lau, Axel Guenther, Lidan You (2011) “Apoptotic Osteocytes Promote In Vitro Osteoclastogenesis Directly through RANKL and Indirectly Through M-CSF and VEGF” 2011 American Society of Bone and Mineral Research Annual Meeting, September 16-20, 2011, San Diego, California, USA. (Plenary poster, ASBMR Young Investigator Travel Grant, UofT SGS Travel Grant)
  • Chao Liu, Lidan You (2011) “Responses of Osteocytes to Microdamage in vitro” 2011 American Society of Bone and Mineral Research Annual Meeting, September 16-20, 2011, San Diego, California, USA. (Poster, UofT SGS Travel Grant)
  • Saja Al-Dujaili, Chao Liu, Axel Guenther, Lidan You (2012) “Osteocytes exhibit multiple calcium oscillations in response to mechanical loading” ORS 58th Annual Meeting, February 4-7, 2012, San Francisco, California, USA. (Podium, UofT SGS Travel Grant, CIHR Travel Grant)
  • Jia Ning Zhang, Chao Liu, Lidan You (2012) “The Effect of Mechanical Stimulation on Osteocyte Chemo-Sensitivity” ORS 58th Annual Meeting, February 4-7, 2012, San Francisco, California, USA. (Poster, UofT SGS Travel Grant, CITH Travel Grant)
  • Dawei Liu, Chao Liu, Lidan You (2012) “Mechanical Vibration in Differential Responses in Osteocytes Verse Cementoblasts” 41st Annual Meeting & Exhibition of the American Association for Dental Research, March 21-24, Tempa, Florida, USA
  • Lidan You (2012) “Osteocyte Mechanobiology” The sixth International Congress on Advanced Orthopaedics and Clinical Translational Research (OTR), May 19-20, 2012 in Shanghai. (Podium, invited speaker)
  • Wing-Yee Cheung, Craig Simmons, Lidan You (2012) “Effect of osteocyte apoptosis on osteoclast precursor recruitment” 18th Canadian Connective Tissue Conference, June 8-10, 2012. Toronto. (Podium)
  • Jia Ning Zhang, Chao Liu, Lidan You (2012) “The Effect of Mechanical Stimulation on Osteocyte Chemo-Sensitivity” 18th Canadian Connective Tissue Conference, June 8-10, 2012. Toronto. (Poster)
  • Saja Al-Dujaili, Chao Liu, Axel Guenther, Lidan You (2012) “Osteocytes exhibit multiple calcium oscillations in response to mechanical loading” 18th Canadian Connective Tissue Conference, June 8-10, 2012. Toronto. (Poster)
  • Chao Liu, Lidan You (2012) “In Vitro Investigation of Osteocyte Response to Microdamage” 18th Canadian Connective Tissue Conference, June 8-10, 2012. Toronto. (Poster, Best Poster Award)
  • Lidan You (2013) “Osteocyte Mechanobiology” 2nd Annual Biomedical Engineering Symposium at McMaster University. Jan 10-12, 2013 (Keynote, invited speaker)
  • Hashem Al-Dujaili, Christian Fischer, Saja Al-Dujaili, Lidan You (2013) “Apoptotic Osteocytes Promote Chondrocyte Apoptosis and Prevent Chondrogenesis via Soluble Factors” ORS 59th Annual Meeting, January 26-29, 2013, San Antonio, USA.  (Poster).
  • Chao Liu; Hashem Al-Dujaili, Christian Fischer; Liyun Wang, Lidan You (2013) “Altered Osteocyte Mechanosensitivity in Response to Elevated Extracellular Glucose Levels” ORS 59th Annual Meeting, January 26-29, 2013, San Antonio, USA.  (Poster, CIHR-IMHA Travel Award)
  • Jia Ning Zhang, Chao Liu, Lidan You (2013) “The Effect of Mechanical Stimulation on Osteocyte Chemo-Sensitivity” ORS 59th Annual Meeting, January 26-29, 2013, San Antonio, USA.  (Poster)
  • Lidan You (2013) “Bone cell mechanotransduction” Department of Mathematics, University of British Columbia, Feb. 28, 2013 (Invited Talk)
  • Lidan You (2013) “Bone cell mechanotransduction” Chinese Academy of Sciences, April 18, 2013. (Invited Talk)
  • Lidan You (2013) “Bone cell mechanotransduction” Peking University, April 19, 2013. (Invited Talk)
  • Lidan You (2013) “In memory of Dr. Wangyi Wu” Beijing, 5th Sino-American Workshop on Biomedical Engineering and China-Oversea Joint Workshop on Biomechanics, August 1-5, 2013 (Invited speaker)
  • Chao Liu; Hashem Al-Dujaili, Christian Fischer; Liyun Wang, Lidan You (2013) “Altered Osteocyte Mechanosensitivity in Response to Elevated Extracellular Glucose Levels” 19th Canadian Connective Tissue Conference, 2013, May 29-June 1st, Montreal, Quebec, Canada.  (Poster, best poster presentation)
  • Chao Liu, Hashem Al-Dujaili, Christian Fischer, Liyun Wang, Lidan You (2013) “Altered Osteocyte Mechanosensitivity in Response to Elevated Extracellular Glucose Levels” ASBMR 2013 Annual Meeting, October 4-7, 2013, Baltimore, USA. (Poster, UofT SGS conference grant，CIHR travel grant)
  1. Lidan You (2013) “Osteocyte Mechanobiolgy” Department of Mechanical and Manufacturing Engineering, University of Calgary, October 10, 2013. (Invited Talk)
  1. Chao Liu, Xiaoqing Zhang, Michael Wu, Lidan You (2014) “Mechanical Regulation of Osteocyte Responses to Microdamage in vitro” 60th Annual meeting of ORS, March 15-18, New Orleans, USA. (Poster, selected for conference poster tour, CIHR travel award)
  1. Kelvin Middleton, Lidan You (2014) “A Microfluidic System to Study the Effects of Mechanically Loaded Osteocytes on Osteoclast Function” Ontario on a Chip, May 29-30, 2014, Toronto, Ontario, Canada. (Podium)
  1. Chao Liu, Xiaoqing Zhang, Michael Wu, Lidan You (2014) “Mechanical Regulation of Osteocyte Responses to Microdamage in vitro” Canadian Society of Mechanical Engineering International Congress 2014,  June 1-4, Toronto, Ontario, Canada. (Podium)
  1. Kelvin Middleton, Lidan You (2014) “Development of a Microfluidic System to Investigate Bone Cell Signaling” Canadian Society of Mechanical Engineering International Congress 2014, June 1-4, Toronto, Ontario, Canada. (Podium)
  1. Yu-Heng Vivian Ma, Lidan You (2014) “Conditioned Medium from Osteocyte-Like Cells Exposed to Mechanical Loading Attracts Breast Cancer Cells” Canadian Society of Mechanical Engineering International Congress 2014, June 1-4, Toronto, Ontario, Canada. (Podium)
  1. Yu-Heng Vivian Ma, Chao Liu, Lidan You (2014) “Osteocytes’ Response to Mechanical Loading Supports Breast Cancer Cell Growth and Migration” 20th Canadian Connective Tissue Conference June 8-10, 2014, London, Ontario, Canada. (Poster)
  1. Chao Liu, Xiaoqing Zhang, Michael Wu, Lidan You (2014) “Mechanical Regulation of Osteocyte Responses to Microdamage in vitro” 20th Canadian Connective Tissue Conference June 8-10, 2014, London, Ontario, Canada. (Poster)
  1. Kelvin Middleton, Lidan You (2014) “Development of a Microfluidic System to Investigate Bone Cell Signaling” Lidan You (2014) 20th Canadian Connective Tissue Conference June 8-10, 2014, London, Ontario, Canada. (Poster, UofT SGS travel award)
  1. Kevin Middleton, Xueting Mei, Lidan You (2014) “A Microfluidic System to Study the Effects of Mechanically Loaded Osteocytes on Osteoclast Migration and Differentiation” 12th International Bone Fluid Flow Workshop, September 10-11, 2014, Houston, Texas, Unites States. (Podium, IBFF travel award, Invited speaker)
  1. Chao Liu, Xiaoqing Zhang, Michael Wu, Lidan You (2014) “Microdamage and Mechanical Loading Have an Interactive Effect on Remodeling Signals Produced by Osteocyte” 12th International Bone Fluid Flow Workshop, September 10-11, 2014, Houston, Texas, Unites States. (Poster, IBFF travel award)
  1. Yu-Heng Vivian Ma, Chao Liu, Peter Gao, Shreyash Dalmia, Lidan You (2014) “Osteocytes’ Response to Mechanical Loading Supports Breast Cancer Cell Growth and Migration” 12th International Bone Fluid Flow Workshop, September 10-11, 2014, Houston, Texas, Unites States. (Poster, IBFF travel award)
  1. Kevin Middleton, Xueting Mei, Bin Deng, Wei Chao, Jian Chen, Junbo Wang, Lidan You (2014) “Microfluidic platform for bone cell mechanobiology” 12th International Bone Fluid Flow Workshop, September 10-11, 2014, Houston, Texas, Unites States. (Podium, Invited Speaker, Scientific and organizing committee member)
  1. Yu-Heng Vivian Ma, Lidan You (2014) “Osteocytes’ Response to Mechanical Loading Supports Breast Cancer Cell Growth and Migration” Annual Meeting – American Society of Bone and Mineral Research, September 12-15, 2014, Houston, Texas, United States. (Poster, UofT SGS Travel Award, CIHR Travel Award)
  1. Chao Liu, Xiaoqing Zhang, Michael Wu, Lidan You (2014) “Microdamage and Mechanical Loading Have an Interactive Effect on Remodeling Signals Produced by Osteocyte “Annual Meeting – American Society of Bone and Mineral Research, September 12-15, 2014, Houston, Texas, United States. (Poster)
  1. Kelvin Middleton, Lidan You (2014) “A Microfluidic System to Study the Effects of Mechanically Loaded Osteocytes on Osteoclast Function” Annual Meeting – American Society of Bone and Mineral Research, September 12-15, 2014, Houston, Texas, United States. (Poster)
  1. Yu-Heng Vivian Ma, Lidan You (2014) “Osteocytes’ Response to Mechanical Loading Supports Breast Cancer Cell Growth and Migration” Biomedical Engineering Society 2014 Annual Meeting, October 22-25, 2014, San Antonio, Texas, Unites States. (Poster)
  1. Kelvin Middleton, Lidan You (2014) “A Microfluidic System to Study the Effects of Mechanically Loaded Osteocytes on Osteoclast Function” Biomedical Engineering Society 2014 Annual Meeting, October 22-25, 2014, San Antonio, Texas, Unites States. (Poster)
  1. Chao Wei, Deyong Chen, Yuanchen Wei, Lidan You, Junbo Wang, and Jian Chen (2014) “On-Chip culture of Osteocytes” The 18th International Conference on  Miniaturized Systems for Chemistry and Life Sciences (microTAS 2014), October 26-30, San Antonio, Texas, United States. (Poster)
  1. Kelvin Middleton, Lidan You (2014) “A Microfluidic System to Study the Effects of Mechanically Loaded Osteocytes on Osteoclast Function” The 18th International Conference on  Miniaturized Systems for Chemistry and Life Sciences (microTAS 2014), October 26-30, San Antonio, Texas, United States. (Poster, NSERC CREAT MATCH Travel Award)
  1. Chao Liu, Xiaoqing Zhang, Michael Wu, Lidan You (2015) “Microdamage and Mechanical Loading Have an Interactive Effect on Remodeling Signals Produced by Osteocyte” Orthopaedic Research Society 2015 Annual Meeting, March 28-31, Las Vegas, Nevada, Unites States. (Poster)
  1. Avinash Kondiboyina, Kevin Middleton, Mike Borrett, Christina Mei, Lidan You (2015) “Analyzing the Effect of the Reynolds Number of Flow on Osteocytes” Orthopaedic Research Society 2015 Annual Meeting, March 28-31, Las Vegas, Nevada, Unites States. (Poster)
  1. Kevin Middleton, Xueting Christina Mei, Lidan You (2015) “A Microfluidic System to Study the Osteocytes and Osteoclasts Communication on Bone Remodelling Process under Loading” Orthopaedic Research Society 2015 Annual Meeting, March 28-31, Las Vegas, Nevada, Unites States. (Poster)
  1. Yu-Heng Vivian Ma,Peter Gao, Shreyash Dalmia,Chao Liu, Lidan You (2015) “Osteocytes’ Response to Mechanical Loading Supports Breast Cancer Cell Growth and Migration”  Orthopaedic Research Society 2015 Annual Meeting, March 28-31, Las Vegas, Nevada, Unites States. (Poster)
  1. Cheryl Druchok, Lidan You, Gregory R. Wohl (2015) “Timing of Indomethacin Administration and the PGE2 Response of MLO-Y4 Cells to Fluid-Flow Induced Shear Stress” Emerging Research in Bone Health: Preventative and Maintenance Strategies, April 30, Catharines, Ontario, Canada. (Poster)
  1. Kevin Middleton, Danny Cen, Xueting Mei, Lidan You (2015) “Microfluidic Co-Culture Device For Investigating Cell Interactions During Mechanical Stimulation”, Biomedical Engineering Society 2015 Annual Meeting, October 7-10, 2015, Tampa, Florida, Unites States. (Poster)
  1. Lidan You (2015) “Bone cell mechanobiology” 2nd Advanced Workshop on Biomechanics and Computational Medicine, Beijing, China. July 3-5, 2015. (Invited Speaker)
  1. Cheryl Druchok, Lidan You, Gregory Wohl (2015) “Timing of Indomethacin Administration Causes Differential PGE2 Response in Fluid Shear Stress Stimulated MLO-Y4 Cell” American Society of Bone and Mineral Research 2015 Annual Meeting, Oct. 9-12, 2015, Seattle, Washington, United States. (Poster)
  1. Kevin Middleton, Avinash Kondiboyina, Yi Cui, Michael Borret, Xueting Mei, Lidan You (2016) “Osteocyte are Sensitive to the Reynolds Number of Fluid Flow Given a Constant Fluid Shear Stress and Flow Rate” Orthopaedic Research Society Annual Meeting, March 5-8, 2016, Orlando, Florida, United States. (Poster)
  1. Yu-Heng Ma, Shreyash Dalmia, Peter Gao, Jacob Young, Chao Liu, Lidan You (2016) “Osteocytes Response to Mechanical Loading Supports Cancer Cell Growth and Migration, but Reduces Osteoclasts Support of Cancer Cells” Orthopaedic Research Society Annual Meeting, March 5-8, 2016, Orlando, Florida, United States. (Poster)
  1. Miranda M. Carleton, Madeleine Bareau, Lidan You (2016) “Investigating Effects of Diabetes and Diabetic Treatments on Mechanically Loaded Bone Cells” Orthopaedic Research Society Annual Meeting, March 5-8, 2016, Orlando, Florida, United States. (Poster)
  1. Lidan You (2016) “Bone Cell Mechanobiology” June 3rd, 2016, Northwestern Polytechnical University, Xi’an, China. (Invited talk)
  1. Lidan You (2016) “Bone-On-A-Chip” August 4-8, 2016, the Sino-American Workshop on Biomedical Engineering and China-Oversea Joint Workshop on Biomechanics, August 4-8, 2016, Shanghai, China (Invited talk)
  1. Lidan You (2016) “Bone Cell Mechanobiology” June 15, 2016, University of Pennsylvania, Philadelphia, PA, USA. (Invited talk)
  1.  Lidan You (2016) “Bone Cell Mechanobiology” June 14, 2016 University of Delaware, Newark, DE, USA. (Invited talk)
  1.  Lidan You (2016) “Osteocytes as regulator of effector cells in disease condition” 13th International Bone Fluid Flow Workshop, Sep. 15, 2016, Atlanta, USA. (Invited talk)
  1.  Lidan You (2016) “Bone Cell inter-cellular cross talk and regulation” August 9, 2016, Southern University of Science and Technology, Shen Zhen, China. (Invited talk)
  1. Yu-Heng Ma, Lidan You (2016) “Osteocytes’ Response to Mechanical Loading Supports Cancer Cell Growth and Migration, but Reduces Osteoclasts’s Support of Cancer Cells”, 71st Canadian Orthopaedic Association (COA) Annual Meeting and 50th Canadian Operational Research Society (CORS) Annual Meeting, June 16-19, 2016 Quebec City, Quebec, Canada. (Podium)
  1. Madeleine Bareau, Lidan You (2016) “Investigating Effects of Diabetes and Diabetic Treatments on Mechanically Loaded Bone Cells” 71st Canadian Orthopaedic Association (COA) Annual Meeting and 50th Canadian Operational Research Society (CORS) Annual Meeting, June 16-19, 2016 Quebec City, Quebec, Canada. (Poster, High Score Poster highlighted in President’s reception of the conference)
  1. Cheryl Druchok, Lidan You, Gregory Wohl (2016) “Timing of Indomethacin Administration Causes Differential PGE2 Response in Fluid Shear Stress Stimulated MLO-Y4 Cell” 71st Canadian Orthopaedic Association (COA) Annual Meeting and 50th Canadian Operational Research Society (CORS) Annual Meeting, June 16-19, 2016 Quebec City, Quebec, Canada. (Poster, High Score Poster highlighted in President’s reception of the conference)
  1. Liangcheng Henry Xu, Lidan You (2017) “Creating Novel High-Throughput Microfluidic Platform for Osteocyte Mechanotransduction Studies” Orthopaedic Research Society Annual Meeting, March 19-22, 2017, San Diego, California, United States. (Poster 1654)
  1. KevinMiddleton, Dongsub Shim, Deepika Devadas, Yu-Heng Ma, Edmond Young, Lidan You (2017) “Microfluidic Platform to Investigate the Role of Osteocytes on the Mechanical Regulation of Bone Metastasis” Orthopaedic Research Society Annual Meeting, March 19-22, 2017, San Diego, California, United States. (Poster 1655)
  1. Yu-Heng Ma, Candy Lam, Shreyash Dalmia, Peter Gao, Jacob Young, Chao Liu, Kevin Middleton, Lidan You (2017) “Mechanical Regulation of Breast Cancer Bone Metastasis via Osteocytes” Orthopaedic Research Society Annual Meeting, March 19-22, 2017, San Diego, California, United States. (Poster 1650)
  1. Xueting Mei, Kevin Middleton, Qianqian Wan, Dongsub Shim, Liangcheng Xu, Yu-Heng Ma, Deepica Devadas, Noosheen Walji, Edmond Young, Lidan You (2018) “Microfluidic Platform for Investigation of Mechanoregulation of Breast Cancer Bone Metastasis” 2018 Canadian Connective Tissue Conference, Toronto, May, 2018 (Podium, 3rd place for Oral presentation)
  1. Liangcheng Xu, Lilia Fuller-Thomson, Lidan You (2018) “Novel in vitro Microfluidic Platforms for Osteocyte Mechanotransduction Studies” 2018 Canadian Connective Tissue Conference, Toronto, May, 2018 (Poster, 1st place prize for poster presentation)
  1. Xueting Mei, Kevin Middleton, Qianqian Wan, Dongsub Shim, Liangcheng Xu, Yu-Heng Ma, Deepica Devadas, Noosheen Walji, Edmond Young, Lidan You (2018) “Microfluidic Platform for Investigation of Mechanoregulation of Breast Cancer Bone Metastasis” 2018 UofT MIE Research Symposium, Toronto, June, 2018 (Podium, 1st place for Oral presentation)
  1. Jiachen Zhang, Onaizah Onaizah, Kevin Middleton, Lidan You, Eric D. Diller (2017) “Robust Grasping of Three-Dimensional Untethered Mobile Magnetic Microgripper for Autonomous Pick-and-Place Tasks the 2017 IEEE International Conference on Robotics and Automation, May 29 – June 3, 2017, Singapore.
  1.  Liangcheng Xu, Lilia Fuller-Thomson, Lidan You (2018) “Novel in vitro Microfluidic Platforms for Osteocyte Mechanotransduction Studies” 2018 American Society of Bone and Mineral Research Annual Meeting, Sep. 28-Oct. 1, 2018, Montreal, Canada. (Poster)
  1. Lidan You (2018) “Mechanical Regulation of Bone Metastasis via Osteocytes – a Microfluidics Approach” The 12th International Congress on Orthopaedic Advanced Techniques and Clinical Translational Research. Shanghai, China. May 4, 2018. (Keynote, Invited Talk)
  1. Lidan You (2018) “Bone Cell Cross Talk Under Mechanical Loading” East China University of Science and Technology, Shanghai, China. May 6, 2018. (Invited Talk)
  1. Lidan You (2018) “Mechanical Segregation, Capture of Multiple Myeloma Cells in Peripheral Blood Using Microfluidic Platform”, Annual meeting of Guangdong Orthopaedic Association, Guang Zhou, Guang Dong, China. May 7, 2018. (Invited Talk)
  1. Lidan You (2018) “Microfluidic Platform for Bone Mechanobiology Study” Guangdong Medical University, Dong Guan, Guang Dong, China. May 8, 2018. (Invited Talk)
  1. Lidan You (2018) “Osteocyte Mechanobiology Study” Southern University of Science and Technology, Shen Zhen, China. May 9, 2018 (Invited Talk)
  1. Xueting Mei, Kevin Middleton, Yu-Heng Ma, Liangcheng Xu, Noosheen Walji, Edmond Young, Lidan You (2018) “Microfluidic Platform for Investigation of Mechanoregulation of Breast Cancer Bone Metastasis” 2018 American Society of Bone and Mineral Research Annual Meeting, Sep. 28-Oct. 1, 2018, Montreal, Canada. (Poster)
  1. Yu-Heng Vivian Ma, Liangcheng Xu, Xueting Mei, Lidan You (2018) “Mechanical Regulation of Breast Cancer Bone Metastasis via Osteocytes’ Signaling to Endothelial Cells” 2018 American Society of Bone and Mineral Research Annual Meeting, Sep. 28-Oct. 1, 2018, Montreal, Canada. (Poster)
  1. Lidan You (2018) “Bone Cell Cross-talk Under Mechanical Loading” Health Science Centre, College of Dentistry, Texas A&M University, Dallas, Texas, United States. Oct. 24, 2018. (Pathways to Excellence Seminar Series, Invited Talk)
  1. Xueting Mei, Kevin Middleton, Qianqian Wan, Dongsub Shim, Liangcheng Xu, Yu-Heng Ma, Deepica Devadas, Noosheen Walji, Edmond Young, Lidan You (2019) “Microfluidic Platform for Investigation of Mechanoregulation of Breast Cancer Bone Metastasis” 2019 Orthopaedic Research Society Annual Meeting, Paper No. 0082. Feb. 2-5, 2019, Austin, USA. (Podium)
  1. Yu-Heng Vivian Ma, Liangcheng Xu, Xueting Mei, Lidan You (2019) “Mechanically stimulated osteocytes reduce the bone-metastatic potential of breast cancer cells in vitro by signalling through endothelial cells” 2019 Orthopaedic Research Society Annual Meeting, Paper No. 0111. Feb. 2-5, 2019, Austin, USA. (Podium)
  1. Liangcheng Henry Xu, Han Shao, Lidan You (2019) “Bone Cell Mechanotransduction via OCY454 Osteocytes” 2019 Orthopaedic Research Society Annual Meeting, Paper No. 0246. Feb. 2-5, 2019, Austin, USA. (Podium)
  1.  Liangcheng Henry Xu, Han Shao, Lidan You (2019) “Novel in vitro microfluidic platforms for osteocyte mechanotransduction studies” 2019 Collaborative Program in Musculoskeletal Sciences 7th Annual Research Day, Apr. 25, 2019, Toronto, Canada. (Podium)
  1. Lidan You (2019) “Bone Mechanobiology on a Chip” Canadian Connective Tissue Conference Annual Meeting, May 29-31, 2019 Montreal, QC, Canada. (Keynote, Invited Talk)
  1. Lidan You (2019) “Mechanobiology-on-a-chip for Bone” the 7th Sino-American Workshop on Biomedical Engineering and Biomechanics occurring on July 21-25 2019, in Chongqing, China  (Keynote, Invited Talk)
  1. Dongfang Ouyang, Bin Tang, Wenqi He, Weicong Lin, Jaewon Park, Lidan You (2019) “An innovative microfluidic device to diagnosis Multiple Myeloma by mechanically capturing Circulating Clonal Plasma Cells in peripheral blood” 2019 Guangdong Blood Purification Annual Conference July 26-28, Guangzhou, Guangdong, China.  (Podium)
  1. Dongfang Ouyang, Bin Tang, Wenqi He, Weicong Lin, Jaewon Park, Lidan You (2019) “An innovative microfluidic device to diagnosis Multiple Myeloma by mechanically capturing Circulating Clonal Plasma Cells in peripheral blood”  The 4th International Chinese Musculoskeletal Research Conference (ICMRC-2019) Aug. 9-12, 2019, Shenzhen, Guangdong, China  (Podium)
  1. Lidan You (2019) “Bone Cell Mechanobiology” 16th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering and 4th Conference on Imaging and Visualization. Aug. 14-16, New York, Unites States. (Keynote, Invited Talk)
  1. Lidan You (2019) “Bone Cell Cross Talk Under Mechanical Loading” Invited Seminar, Oct. 16, 2019, Department of Mechanical Engineering, Villanova University, Villanova, PA, USA. (Invited Talk)
  1. Dongfang Ouyang, Yonghua Li, Jaewon Park, Bin Tang, Lidan You (2019) “Mechanical Segregation and Capturing of Clonal Circulating Plasma Cells In Multiple Myeloma Using Micropillar-Integrated Microfluidic Device” 2019 Biomedical Engineering Society Annual Meeting, Poster #1379. Oct. 16-19, 2019, Philadelphia, United States. (Poster)
  1. Jeremy Saget, Marco Montoya, Ariel Seebarran; Pouya Ahmadian; Raem Naveed, Lidan You (2019) “Development of a lower body negative pressure sleeping bag for use in long duration spaceflight” The 70th International Astronautical Congress 2019, 21-25 October 2019, Washington D.C., United States
  1. Dongfang Ouyang, Yonghua Li, Jaewon Park, Bin Tang, Lidan You (2019) “Mechanical Segregation and Capturing of Clonal Circulating Plasma Cells In Multiple Myeloma Using Micropillar-Integrated Microfluidic Device” 2019 Guangdong-HK-Macao Great Bay Area Biomechanics Conference, ShenZhen, Guangdong, China.
  1. Dongfang Ouyang, Yonghua Li, Jaewon Park, Bin Tang, Lidan You (2019) “Mechanical Segregation and Capturing of Clonal Circulating Plasma Cells In Multiple Myeloma Using Micropillar-Integrated Microfluidic Device” Invited Talk, 2019 Shenzhen City Cancer-Center Hospital
  1. Shubo Wang, Shaopeng Pei, Jerahme Martinez, Lidan You, Liyun Wang (2020) “In vivo effects of treadmill running and unilateral tibial loading on breast cancer induced osteolytic lesions in bone” 2020 Orthopaedic Research Society Annual Meeting, Feb. 8-11, 2020, Phoenix, USA. (Podium)
  1. Liangcheng Henry Xu, Xin Song, Gwennyth Carroll, Rafi Bienenstock, Dustin Yang, Lidan You (2020) “Novel in vitro Microfluidic Co-culture Platforms for Osteocyte Mechanotransduction Studies” 2020 Orthopaedic Research Society Annual Meeting, Feb. 8-11, 2020, Phoenix, USA. (Podium)

3.5   Invited Presentations  

  1. “Strain amplification in bone”, Department of Mechanical Engineering, Peking University July 20th, 2000
  • “A new understanding of osteocyte process ultrastructure”, the 24th Annual International Conference of the EMBS and Annual Fall Meeting of the BMES, Houston, TX, 2002
  • “Ultrastructure of Osteocyte Process” Symposium on the Mechanics of Physicochemical and Electromechanical Interactions in Porous Media, Rolduc Kerkrade, Netherlands, May 18-23, 2003
  • “Proliferation rate regulation by oscillatory fluid flow in stem cells” The 50th Annual Meeting of American College of Sports Medicine, San Francisco, CA, May 28-31, 2003
  • “Microfluidics system for bone cell mechanotransduction study” Bio-X, Stanford University, Jan. 20th, 2004
  • “Mechanotransduction in Bone: Cellular Mechanism” Department of Bioengineering, Beijing University of Aeronautics and Astronautics, Beijing, China, May 17th, 2007
  •  “Mechanotransduction in Bone: Cellular Mechanism”  Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China, May 18th, 2007
  •  “Mechanotransduction in Bone: Cellular Mechanism” National Microgravity Laboratory and Center for Biomechanics and Bioengineering, Institute of Mechanics, Chinese Academy of Sciences, May 18th, 2007
  • “Microsystems to study the bone cell mechanotransduction” Ontario-On-A-Chip Forum, Toronto, June 7th, 2007
  1. “Bone cell mechanotransduction” CIHR Matrix Group, University of Toronto, July 21, 2008
  1. “Mechanical Regulation of cells that regulate bone” Department of Biomedical Engineering, City University of New York. June 10th, 2009.
  1. “Mechanical Regulation of bone cells” Department of Biomedical Engineering, Columbus University, June 11th, 2009.
  1. “Bone cell mechanotransduction” Department of Mechanical Engineering, University of Delaware, September 18th, 2009.
  1. “Osteocyte regulation of bone remolding under mechanical loading” The Orthopaedic Biomechanics Workshop, July 24-25, 2010, Shanghai, China.
  1. “Bone cell biomechanics” Biomechanics Workshop, ChongQing, China. July 26-30, 2010.
  1. “Micropatterned Surface for Bone cell mechanobiology” 6th World Congress on Biomechanics, August 1-6, 2010, Singapore.
  1. “Bone cell mechanotransduction” Bioengineering of Skeletal Tissue Team, University of Toronto, December 16, 2011
  1. “Bone cell mechanotransduction” CIHR Matrix Group, University of Toronto, April 09, 2012
  1.  “Osteocyte Mechanobiology” The sixth International Congress on Advanced Orthopaedics and Clinical Translational Research (OTR), May 19-20, 2012 in Shanghai. 
  • “Osteocyte regulation under mechanical loading” Keynote speaker. 2nd annual Biomedical Engineering Symposium, McMaster University, January 10, 2013
  • “Bone cell mechanotransduction” Department of Mathematics, University of British Columbia, Feb. 28, 2013
  •  “Bone cell mechanotransduction” Chinese Academy of Sciences, April 18, 2013.
  •  “Bone cell mechanotransduction” Peking University, April 19, 2013.
  •  “In memory of Dr. Wangyi Wu” Beijing, 5th Sino-American Workshop on Biomedical Engineering and China-Oversea Joint Workshop on Biomechanics, August 5, 2013
  • “Osteocyte Mechanobiolgy”  Department of Mechanical and Manufacturing Engineering, University of Calgary, October 10, 2013.
  • “Microfluidic platform for bone cell mechanobiology study” 14th International Bone Fluid Flow Workshop, Houston, TX, September 10-11, 2014.
  • “Bone cell mechanobiology” 2nd Advanced Workshop on Biomechanics and Computational Medicine, Beijing, China. July 3-5, 2015.
  •  “Bone Cell Mechanobiology”, Northwestern Polytechnical University, Xi’an, China., June 3rd, 2016
  •  “Bone-On-A-Chip” the Sino-American Workshop on Biomedical Engineering and China-Oversea Joint Workshop on Biomechanics, Shanghai, China, August 4-8, 2016
  • “Bone Cell Mechanobiology”, University of Pennsylvania, Philadelphia, PA, USA, June 15, 2016.
  •  “Bone Cell Mechanobiology” University of Delaware, Newark, DE, USA, June 14, 2016
  •  “Osteocytes as regulator of effector cells in disease condition” 13th International Bone Fluid Flow Workshop, Atlanta, USA, Sep. 15, 2016
  •  “Bone Cell inter-cellular cross talk and regulation”, Southern University of Science and Technology, Shen Zhen, China. August 9, 2016.
  • “Mechanical Regulation of Bone Metastasis via Osteocytes – a Microfluidics Approach” The 12th International Congress on Orthopaedic Advanced Techniques and Clinical Translational Research. Shanghai, China. May 4, 2018.
  • “Bone Cell Cross Talk Under Mechanical Loading” East China University of Science and Technology, Shanghai, China. May 6, 2018.
  • “Mechanical Segregation, Capture of Multiple Myeloma Cells in Peripheral Blood Using Microfluidic Platform”, Keynote speaker , Annual meeting of Guangdong Orthopaedic Association, Guang Zhou, Guang Dong, China. May 7, 2018.
  • “Microfluidic Platform for Bone Mechanobiology Study”, Guangdong Medical University, Dong Guan, Guang Dong, China. May 8, 2018.
  • “Osteocyte Mechanobiology Study” Southern University of Science and Technology, Shen Zhen, China. May 9, 2018
  • “Bone Cell Cross-talk Under Mechanical Loading” Health Science Centre, College of Dentistry, Texas A&M University, Dallas, Texas, United States. Oct. 24, 2018.
  • “Bone Mechanobiology on a Chip” Keynote speaker, CCTC, May 29-31, Montreal, QC, Canada
  • “Mechanobiology-on-a-chip for Bone”, the 7th Sino-American Workshop on Biomedical Engineering and Biomechanics occurring on July 21-25 2019, in Chongqing, China
  • “Bone Cell Mechanobiology” Keynote speaker, 16th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering and 4th Conference on Imaging and Visualization. Aug. 14-16, New York, Unites States.
  • “Bone Cell Cross Talk Under Mechanical Loading”, Oct. 16, 2019, Department of Mechanical Engineering, Villanova University, Villanova, PA, USA.


3.6   Career development (e.g., evidence of international leadership):

2010 World Congress on Biomechanics. Co-Chair of Micro/Nano Devices and BioMEMS for Biomedical Imaging  symposium, 6th WCB 2010
2010 International Chinese Hard Tissue Society ASBMR meeting organize committee
2010 11th International Bone Fluid Flow Workshop organize committee chair
2011 Peking University Biomechanics and Bioimaging Advanced Workshop Organizing Committee
2011 Editorial Board Member of the Journal of Tissue Science & Engineering.
2012 18th Annual Canadian Connective Tissue Conference Scientific Board member and session chair of Biomechanics, Mechanobiology, and Biomaterials, June 10, 2012, Toronto.
2014 Canadian Society of Mechanical Engineering Annual Meeting Cell Mechanics and Mechanobiology Symposium  chair
2014 12th International Bone Fluid Flow Workshop Scientific and Organizing committee
2015 Peking University Biomechanics and Bioimaging Advanced Workshop Organizing Committee
2015 IC-IMPACTs – Canada-India Research Centre of Excellence external reviewer
2016 NIH Skeletal Biology Structure and Regeneration Study Section Ad Hoc reviewer
2016 New Zealand Marsden Fund external reviewer
2017 NIH Skeletal Biology Structure and Regeneration Study Section Ad Hoc reviewer
2017 Chinese Society of Theoretical Applied Mechanics Chinse Mechanics Prize external reviewer
2017 US Bone and Joint Initiative / Bone and Joint Canada Young Investigator Initiative Grant Mentoring and Career Development Program Faculty Mentor
2018 CIHR BME Panel member
2018 Irish Research Council Laureate Awards external reviewer
2018 ASBMR Session Chair
2018 ICMRS Women Committee Vice Chair
2018 ICMRS Biomechanics Committee Vice Chair
2018-19 Breast Cancer Now Research Grant External Reviewer
2019 US Bone and Joint Initiative / Bone and Joint Canada Young Investigator Initiative Grant Mentoring and Career Development Program Faculty Mentor
2019 ICMRS annual research conference organizing committee member
2019 Panel member: Arthritis Society’s Strategic Operating Grant (SOG) competition
2019 External Reviewer of Breast Cancer Foundation New Zealand

3.7   Research Grants/Contracts/and Equipment Grants

Period Grantor Type Co-grantees Topic Amount
2006-present University of Toronto Start-Up  (operating) PI: Lidan You Cellular and Molecular Biomechanics $160,000
2006 Turner Biosystem Fluorometer Grant   (equipment) PI: Simmons Co-PIs: Radisic and You Turner Biosystems Fluorometer (TSB-380) Grant $3,800
2007 Connaught Start-Up             (operating) PI: You Bone cell mechanotransduction $10,000
2007-2009 Connaught New Staff Matching (operating) PI: You A novel microfluidics system for bone cell mechanotransduction study $30,000
2007 CFI/ORF Leaders Opportunity Fund (equipment) PI: You Laboratory for cellular and molecular biomechanics $100,000
2007-2009 Ontario Neurotrauma Foundation Operating Grant (operating) PI: Craven Co-PI: You and 8 others Intermittent Whole Body Vibration and Passive Standing for Treatment of Sublesional Osteoporosis After Spinal Cord Injury $188,940
2008-2013 NSERC Discovery Grant (operating) PI: You Bone cell mechanotransduction study on a chip $90,000
2009 CFI/ORF New Initiatives Fund (equipment) PI: Sefton Co-PI: You and 9 others Centre for Microfluidic System in Chemistry and Biology $9,375,000
2010-2015 Ontario MRI Early Research Award (training) PI: You Bone Cell Mechanobiology Study on a Chip $150,000
2009-2015 NSERC Collaborative Research and Training Experience Program (CREAT) (training) PI: Sefton Co-PI: You and 8 others Microfluidic Applications and Training in Cardiovascular Health $1,650,000
2008-2009 NSERC Research Tools and Instruments Grant (equipment) PI: Sun Co-PI: You and Simmons A Polscope for non-invasive visualization of meiotic spindle $118,164
2008-2009 NSERC Research Tools and Instruments Grant (equipment) PI: Guenther Co-PI: You and Scholes Integrated Microscale Particle Image Velocimetry and Fluorescent Lifetime Imaging Instrument $118,437
2010-2011 CIHR Meeting, Planning and Dissemination Grant (training) PI: You 11th International Bone Fluid Flow Bone Workshop $17,500
2013-2016 CIHR China-Canada Joint Health Research Initiative (operating) PI: You Bone cell metabolism and functional study under a microfluidics based in vivo like environment $194,000
2013–2014 NSERC Discovery Grant (operating) PI: You Microengineered platforms for bone cell biomechanics study   $22,000
2014-2019 NSERC Discovery Grant (operating) PI: You Microengineered platforms for bone cell mechanobiology study $110,000
2015-2016 NSERC Research Tools and Instruments Grant (equipment) PI: Guenther Co-PI: You and 12 others 3D Printing and Biofabrication Instrument $150,000
2015-2016 NSERC Research Tools and Instruments Grant (equipment) PI: Naguib Co-PI: You and 6 others 3d profilometer for investigation of micro and nanofeatures of advanced materials $135,036
2015-2018 American Diabetes Association Basic Science Award (operating)(Applied Unsuccessfully) PI: You Hyperglycemia, exercise, and diabetic bone disease $150,000
2016-2019 CIHR CHRP (Applied Unsuccessfully) PI: You Co-PI: Sun and 2 others Development of Microdevice Arrays for Understanding and Management of Bone Metastases $524987
2017-2020 CIHR CHRP (Applied Unsuccessfully) PI: You Co-PI: Sun and 3 others Development of Microdevice Arrays for Understanding and Management of Bone Metastases $723962
2017-2018 NSERC Research Tools and Instruments Grant (equipment) PI: Eric Diller Co-PI: You and 2 others Microfabrication Equipment for Magnetic Micro-Mechanical Structures $149891
2017-2018 UofT IBBME Director’s Kick-start PI: You Mechanical regulation of breast cancer bone metastasis $5000
2019-2022 OCE Ontario-Jiangsu Industrial Research and Development Program (Applied Unsuccessfully) PI: You Co-PI: Gong Developing Microfluidic-Based Chip for High-sensitivity Capture and Biological Characterization of Peripheral Blood Circulating Plasma Cells for Multiple Myeloma Diagnosis and Treatment $125000
2019-2022 OCE Ontario-Jiangsu Industrial Research and Development Program (Applied, Program cancelled) PI: You Co-PI: Yao Vibration Device for Disc Disorder Treatment $125000
2019-2022 NIH R21 (Applied, Program unavailable) PI: You Leading PI: Wang Vibration in Breast Cancer Bone Metastasis Prevention $344000
2019-2024 NSERC Discovery Grant (operating) PI: You Bone-On-a-Chip Development $160000
2019-2022 CIHR Project Grants (Applied unsuccessfully) PI: You Vibration as an alternative in Breast Cancer Bone Metastasis Prevention $720,000
2020-2023 NIH R21  (Applied, pending) PI: You Leading PI: Wang Vibration in Breast Cancer Bone Metastasis Prevention $344000
2020-2023 Tri-agency New Frontiers in Research Fund – Exploration (Applied unsuccessfully) Co-PI:You Leading PI: Gopaluni A Machine Learning Guided Workout Strategy to Prevent Metastasis $430,000
2020-2024 CCS Impact Grant (Applied, unsuccessfully) PI: You Efficacy of vibration in overcoming exercise barriers for breast cancer patients $720,000
2020-2023 NSERC CRD (Applied unsuccessfully) Co-PI: You Leading PI: Jane Howe Liquid-phase electron microscopy for probing dynamic process $107,000
2019-2021 UofT UofT-Tsinghua Joint Research Fund (operating) Leading PI: You On-chip parallel mechanical stimulations and analyses of osteocytes for osteoporosis treatment $40,000
2019-2022 UofT MIE Hart Professorship (operating) PI: You Breast cancer regulation under mechanical loading $225,000
2020-2021 NSERC Research Tools and Instruments Grant (equipment) PI: Yu Sun Co-PI: You and 3 others A BioAFM for Intracellular, Cellular, and Tissue Measurement and Manipulation $149,825
           


3.8        Supervisory Experience: Graduate Students

(Completed and current graduate student supervision.  For current supervision, indicate starting date in date column with asterisk)

Date Degree Candidate Thesis Title
2007 M.A.Sc. Yan Zhao S1P signaling pathway in osteocyes
2007 Ph.D. Wing-Yee Cheung Angiogenesis in Bone repair
2007 Ph.D. Saja Al-Dujaili Mechanical regulation of bone remodeling
2007 M.A.Sc. Esther Lau Vibration effect on bone cells
2008 M.A.Sc Chao Liu Pressure effect on bone cells
2008 M.A.Sc Jason Li Nanosensors in bone cell mechanotransduction study
2010 Ph.D. Chao Liu Combined effect of pressure and fluid flow on bone cells
2010 M.A.Sc Johnny Zhang Mechanical regulation of S1P signaling pathway
2012 Ph.D. Kevin Middleton Cell-Cell communication in bone remodeling
2013 Ph.D Yu-Heng Ma Mechanical loading on bone in preventing bone matastasis
2014 M.A.Sc Madeleine Bareau Mechanical Loading effects on bone remodeling in diabetes patient
2015* Ph.D Liangcheng Xu High throughput microfluidic device for osteocyte mechaobiology study
2017 M.A.Sc Xueting Mei Mechanical regulation of cancer cell gene expression
2018* M.A.Sc Ouyang Dongfang Microfluidic chips for MM cell detection.
2019* Ph.D Chunyu Lin Microfluidic platform for bone metastasis study

Career Totals

  Ph.D. 7
  M.A.Sc. 7
  Ph.D. Committee Memberships 52
  MASc Committee Memberships 45


3.9        Thesis Examination Committees

Ph.D exam committee

  Student Dept.* Supervisor(s) Date
1 Christopher Moraes MIE Craig Simmons and Yu Sun 26.03.2007 18.04.2008  
2 Mohammed Jalal Ahamed MIE Ridha Ben Mrad and Pierre Sullivan 16.11.2007 08.10.2009 07.11.2011  
3 Jian Chen MIE Yu Sun 15.02.2008
4 Xinyu Liu MIE Yu Sun 26.09.2007 11.09.2009
5 Keekyoung Kim MIE Yu Sun 25.11.2008
6 Ruogang Zhao MIE Craig Simmons 11.12.2009 10.01.2011
7 Krista Sider MIE Craig Simmons 31.10.2008 09.12.2009 11.01.2012 07.08.2012  
8 Linus Hoi Che Leung MIE Hani Naguib 06.10.2008 16.12.2010 26.09.2011
9 Sai Wing Tsang MSE Zheng-Hong Lu 27.01.2009
10 Dorrin Nilforoushan Dentistry Morris F. Manolson 15.05.2009
11 David Silkstone Surgery Benjamin Alman 11.08.2009 23.07.2010
12 Stanley Wong IBBME Kevin Truong 03.09.2009
13 Kevin Ming IBBME Warren Chan 13.10.2009 20.01.2010 25.10.2010 12.01.2011 13.01.2012 20.12.2013 29.09.2014 02.02.2015 01.05.2015
14 Jane Cheung IBBME Paul Santerre 27.10.2009 25.10.2010 08.11.2011 22.11.2012 27.09.2013 06.10.2014 16.03.2015
15 Cindy Ying Yin Yip IBBME Craig Simmons 11.12.2009
16  Ko Lun (Brandon) Chen MIE Yu Sun 26.10.2010 03.09.2013
17 Suthan Srigunapalan MIE/IBBME Craig Simmons, Aaron  Wheeler 16.08.2010 15.12.2011 25.02.2013 08.08.2013
18 Ronan Rogers Medical Sci John Flanagan 10.02.2012
19 Stephanie Goldberg Dentistry Michael Glogauer, Marc Grynpas 15.05.2015
20 Yi Zheng MIE Yu Sun 16.02.2012 26.07.2012 28.02.2014 19.08.2014
21 Eunji In MIE Hani Naguib 27.09.2012 08.11.2013 16.06.2015 13.04.2016
22 Max Gong MIE David Sinton 05.10.2012 16.01.2014 25.08.2015
23 Simon Kelley Medical Sci Benjamin Alman 19.10.2012 18.12.2012 06.09.2013 01.04.2014 01.12.2014 06.05.2016 21.07.2016
24 Noelle Ochotny Dentistry Morrie Manolson 26.04.2013
25 Xi Chen IBBME Kevin Truong 23.09.2013
26 Yaghoub Dabiri Mechanical and Manufacturing Engineering,, Univ. of Calgary Leping Li 10.10.2013
27 Haijiao Liu MIE Yu Sun & Craig Simmons 03.12.2013 06.05.2014 17.12.2015 22.11.2016 02.05.2017 09.01.2018
28 Jun Liu MIE Yu Sun 28.11.2013 11.04.2016 12.09.2016
29 Gazelle Jean Crasto Dentistry Morrie Manolson 19.12.2013
30 Jessica Yu IBBME Rodrigo Fernandez-Gonzalez 18.06.2014 06.11.2014 19.04.2016 04.05.2017 16.05.2018 06.11.2018 15.05.2019 03.07.2019
31 Mohamed Taher Hassan MIE Shaker A. Meguid 10.12.2014 02.05.2016 18.10.2016 08.07.2019
32 Nemat Hossieny MIE Chul Pak 03.09.2014
33 Stephanie Goldberg Dentistry Michael Glogauer 15.05.2015
34 Aileen Zhong IBBME Craig Simmons 15.06.2015 01.02.2017 02.08.2018 16.01.2019
35 Linda Vi Medical Sci Benjamin Alman 23.03.2016 22.07.2016
36 Birol Ay IBBME John Davis 27.10.2016
37 Roxy Fournier Cell & System Biology Rene Harrison 27.01.2016 13.10.2016 29.01.2018 15.01.2020
         
38 Bryan J. Gellner MIE Jean Zu 08.09.2016 25.09.2017 14.09.2018 23.08.2019
39 Zhuoran Zhang MIE Yu Sun 16.01.2017 15.05.2019 03.09.2019
40 Min Zhu MIE Yu Sun 14.06.2017 16.10.2018 19.11.2019
41 Edwin Wong IBBME Craig Simmons 31.07.2017
42 Benjamin Lai IBBME Milica Radisc 28.09.2017 29.01.2018 13.03.2019
43 Mohamed Ali Emhmed Kshad MIE Hani Naguib 07.12.2017 27.03.2019
44 Ruixin Gao IBBME Eli Sone 15.03.2018
45 Mohamed Taher Z Hassan MIE Shaker Meguid 22.03.2018
46 Mehrnoosh Neshatian Dentistry Bernhard Ganss 18.04.2018
47 Sinthu Pathmanapan IMS Ben Alman 17.08.2018
48 Jiachen Zhang MIE Eric Diller 04.09.2018
49 Abdullah Mosabbir IBBME Kevin Truong 09.10.2018
50 Zhongjie Huang MIE Yu Sun 03.04.2019
51 Mosfera Chowdury MIE Edmond Young 30.08.2019
52 Xiao Sa MIE David Sinton 12.09.2019
53 Zhen Qin MIE Xinyu Liu 13.11.2019
54 Onaizah Onaizah MIE Eric Diller 29.11.2019
55 Alan Lam IBBME Craig Simmons 13.01.2019

*:

  • MIE: Department of Mechanical and Industrial Engineering, University of Toronto
  • IBBME: Institute of Biomaterials and Biomedical Engineering, University of Toronto
  • Dentistry: Faculty of Dentistry, University of Toronto
  • MSE: Department of Material Science and Engineering
  • Surgery: Department of Surgery, University of Toronto
  • IMS: Institute of Medical Science, University of Toronto

Master exam committee

  Student Dept Supervisor(s) Date
1 Derek Randall Watt MIE Craig Simmons 30.10.2007
2 Rano Matta IBBME John E. Davies 17.12.2008 14.08.2009
3 Ming Yin Ho MIE Ridha Ben Mrad, Pierre Sullivan 18.09.2008
4 Kristine Wyss MIE Craig Simmons 25.09.2008
5 Steve Perrault  IBBME Warren Chan 01.08.2008
6 Shadi Rajabi MIE Ross Ethier, Craig Simmons 07.10.2008
7 Ivan Kamikovski IBBME Marc Grynpas 07.04.2009
8 Vanessa Komarnicki IBBME Kevin Truong 14.11.2008 29.07.2009
9 Patricia Joyce Brooks Dentistry Siew-Ging Gong 16.06.2009
10 Albet Hyun Woo Kim Dentistry Bernhard Ganss 23.06.2009 09.08.2010
11 Andrea Heckler Dentistry Siew-Ging Gong, Craig Simmons 06.06.2009
12 Elena Manho Dentistry John E. Davies 20.11.2009 30.09.2010
13 Milad Alizadeh-Meghrazi MIE & IBBMEE Cathy B. Craven, Milos R. Popovic 14.12.2009
14 Joyce K. R. S. Magalhaes Dentistry Michael Glogauer, Marc Grynpas 27.01.2010
15 Adam Hellen Dentistry Andreas Mandelis, Yoav Finer 22.04.2010
16 Keith Kin Kei Fung MIE James Wallace, Lily H. Shu 31.08.2010
17 Hongtao Zhang MIE Chul Park 23.09.2010
18 Herman Thang Dentistry Michael Glogauer, Marc Grynpas 08.18.2010
19 Saber Ghadakzadeh Medical Sci Benjamin Alman 06.07.2011 19.04.2012 01.10.2012 31.07.2013 27.09.2013
20 Bogdan Beca MIE Craig Simmons 11.01.2012
21 Gazelle Crasto Dentistry Morris F. Manolson 30.11.2011
22 Ehsan Shojaei-Baghini MIE Yu Sun 20.09.2012
23 Jonathan Brunetti Chen Eng Alison P McGuigan 20.09.2012
24 Haijiao Liu MIE Yu Sun 25.09.2012
25 Norm Lightstone MIE Craig Simmons 24.10.2012
26 Oleg Chebotarev MIE Craig Simmons 30.10.2012
27 Mortah Nabavi Niaki IBBME Rita Kandel 23.11.2012 09.08.2013 16.01.2014
28 Spencer Bell IBBME John E. Davies 23.01.2013
29 Heather Nicole Ford Dentistry Siew-Ging Gong 27.08.2013
30 Mike Kwon MIE Craig Simmons 26.11.2013 03.09.2014
31 Tony Lin IMS Emil Schemitsch 22.08.2014
32 Natoosha Nargaski Dentistry Morris F. Manolson 13.01.2015
33 Aileen Zhong IBBME Craig Simmons 19.02.2015
34 K M Zamil Andalib MIE Chul Park 02.02.2015 02.09.2015
35 Mouhita Hamuyan MIE Edmond Young 28.09.2016
36 Haozhong Situ IBBME Aaron Wheeler 12.01.2017
37 Janice Wong IBBME Kevin Truong 22.09.2017
38 Ahmed Anwer MIE Hani Naguib 22.08.2018
39 Gabriel Shi MIE Shaker Meguid 07.09.2018
40 Brayden Ridley MIE Shaker Meguid 07.09.2018
41 Nikola Kuzmic MIE Edmond Young 11.09.2018
42 Suzette Guo Dentistry Vanessa Mendes 25.04.2019
43 Taylor Morrison MIE Hani Naguib 28.08.2019
44 Andrew Kuo MIE Edmond Young 06.09.2019
45 Sohrab Roointan MIE Andreas Mandelis 11.09.2019
46 Heta Lad IBBME Penney Gilbert 11.11.2019
47 Alexander Upenieks IBBME Rita Kandel 12.11.2019
48 Sidrah Waseem IBBME Julie Audet 21.02.2020


3.10 International Collaboration Activities

Role Country Institution Collaborator Start Date End Date Project
PI United State University of Delaware Liyun Wang 2008 — Bone fluid flow, bone microdamge, bone disorder
PI United State Marquette University Dawei Liu 2009 2011 Vibration effect on bone
PI Unites State Villanova University Qianhong Wu 2010 2012 Transport; Vibration effect on bone
PI China Chinese Academy of Science Jian Chen 2013 2015 Microfluidic platform for bone mechanobiology study
PI United States Univ. of Pennsylvania Shuying Yang 2015 2016 Osteoblast mechanobiology
PI Ireland National University of Ireland, Galway Laoise McNamara 2017 2018 Bone cell mechanobiology
PI China General Hospital of Guangzhou Military Command of PLA Yang Xiao Yonghua Li 2016 — Myeloma early detection and diagnostic
PI China Shanghai Jiaotong Univ. Tingting Tang 2017 2018 Microfluidic platform for drug screening
PI United States Univ. Texas A&M, College of Dentistry Jerry Feng 2018 — Tendon cell mechanobiology
PI China Tsinghua University Dahai Ren 2019 — On chip analysis for osteoporosis treatment
PI Australia The University of New South Wales Chris Sorrell 2019 — multifunctional layered coatings for polymeric orthopaedic implants

3.11 Services

Youth outreach:

Consultant: Speak to students who attended Sanofi-Aventis BioTalent Challenge (SABC)  competition in the Toronto area. The SABC is a biotechnology science fair for high school students in which we strive to have all projects mentored by professional researchers.  The program is sponsored largely by sanofi-aventis and BioTalent Canada but is also supported by the NRC, CIHR and Genome Canada, the Ontario Ministry of Research and Innovation and over 100 other academic, government and private sector entities across Canada.

Departmental Committees

       (Also list visits to companies for Professional Experience Year (PEY) program, school liaison activity, Open House, science and/or design competitions, etc.)

2007: Mechanical Engineering Top Applicant Luncheon, May 5th, 2007
2008: Talk: “Bone Mechanobiology” to Club for Undergraduate Biomedical Engineering at UofT:. October 29th, 2008  
2009: Talk: “Bone Mechanobiology” to Club for Undergraduate Biomedical Engineering at UofT:. November 4th, 2009  
2009 – current:  MIE Graduate Department Academic Appeals Committee
2010 – current: ASME faculty advisor (September 2010 – current)
2010:Talk: “Bioengineering” to prospected undergraduate students in the March Break Open House undergraduate applicant event, March 13th, 2010.
2011-current: MIE seminar series
2011: Meet female members of Da Vinci Engineering Enrichment Program (DEEP).
2011: IBBME Bioengineering curriculum committee
2012: Graduate Open House Recruiting Event, Feb. 17, 2012
2012: IBBME Summer Research Talk
2012: MIE DEEP lunch for high school students
2012: IBBME PTR committee
2013: IBBME Summer Research Talk
2014: The Reading/Teaching Committee for the 3rd review of a faculty member in IBBME
2014: IBBME Summer Research Talk
2015-19: MIE graduate admission committee
2016-19: MIE Graduate Study Awards committee
2015-17: IBBME Tenure Promotion Teaching Evaluation Committee
2017: MIE graduate Research Symposium Judge
2017-19: Chair: IBBME graduate award committee
2018: IBBME Tenure Promotion Committee
2018-9: MSE Tenure Promotion Teaching Evaluation Committee
2018-19: MSE Tenure Promotion Committee
2018-19: IBBME Distinguished Seminar Series Committee

Faculty Committees (Standing Committees, Task Forces, etc.)

Library Advisory Group (2012 – current)
Community Affairs and Gender Issues (September 2007 – current). Serve as vice chair since July 1st, 2011
Girls Leadership in Engineering Experience event, Faculty of Applied Science and Engineering, University of Toronto. May 26, 2012.
The University of Toronto Space Program (UTSP) Microgravity-Biomedical research cluster coordinator (2009) The University of Toronto Space Program was initiated January 2009. Ten research laboratories in IBBME and Medical Science decided to team up and form the microgravity-Biomedical Science research cluster for collaborative efforts on understanding the problems posed to human physiology by space travel. I was appointed as the coordinator of our research cluster in UTSP program. We have set up a page in UTSP web, and we are in the process of setting up a local web page for our cluster.
Committee on recruiting IBBME new director 2014
Girls Leadership in Engineering Experience event, Faculty of Applied Science and Engineering, University of Toronto. May 26, 2018.

                                Section 4 – Teaching

4.1        Undergraduate Teaching

Year Subject No. and Title No. of Students Year and Course Lect./Week Wt
2007 CHE393 Biotransport Phenomena 25 3rd CHE393 3 0.5
2008 MIE539 Biomechanics II 7 4th, MIE539 3 0.5
2008 CHE393 Biotransport Phenomena 20 3rd CHE393 3 0.5
2009 MIE539 Biomechanics II 4 4th, MIE539 3 0.5
2010 MIE100 Dynamics 100 1st, MIE100 3 0.5
2010 CHE393 Biotransport Phenomena 15 3rd CHE393 3 0.5
2011 CHE393 Biotransport Phenomena 20 3rd CHE393 3 0.5
2012 MIE 100 Dynamics 100 1st, MIE100 3 0.5
2012 MIE520 Biotransport Phenomena 24 4th, MIE520 3 0.5
2013 MIE 100 Dynamics 100 1st, MIE100 3 0.5
2014 MIE520 Biotransport Phenomena 40 4th, MIE520 3 0.5
2015 MIE 100 Dynamics 90 1st, MIE100 3 0.5
2015 MIE520 Biotransport Phenomena 35 4th, MIE520 3 0.5
2016 MIE 100 Dynamics 90 1st, MIE100 3 0.5
2016 MIE520 Biotransport Phenomena 30 4th, MIE520 3 0.5
2017 MIE 100 Dynamics 100 1st, MIE100 3 0.5
2017 MIE520 Biotransport Phenomena 33 4th, MIE520 3 0.5
2018 MIE100 Dynamics 100 1st, MIE100 3 0.5
2018 MIE520 Biotransport Phenomena 40 4th, MIE520 3 0.5
2019 MIE100 Dynamics 100 1st, MIE100 3 0.5
2019 MIE520 Biotransport Phenomena 40 4th, MIE520 3 0.5


4.2        Graduate Teaching

Year Subject No. and Title No. of Students Lect./Week  
Instructor
2009 MIE 1359 Engineering Cell Biology and Micro-Nanoengineered Platforms 8 3  
2010 MIE1359 Engineering Cell Biology and Micro-Nanoengineered Platforms 13 3  
2012 MIE1359 Engineering Cell Biology and Micro-Nanoengineered Platforms 10 3  
2013 MIE1359 Engineering Cell Biology and Micro-Nanoengineered Platforms 7 3  
2015 MIE1359 Engineering Cell Biology and Micro-Nanoengineered Platforms 10 3  
2016 MIE1359 Engineering Cell Biology and Micro-Nanoengineered Platforms 12 3  
2017 MIE1359 Engineering Cell Biology and Micro-Nanoengineered Platforms 15 3  
2018 MIE1359 Engineering Cell Biology and Micro-Nanoengineered Platforms 14 3  
2019 MIE1359 Engineering Cell Biology and Micro-Nanoengineered Platforms 26 3  
 

4.3        Undergraduate Thesis Supervision

Year Student Name Thesis Topic
2009-10 Jianing Zhang S1P role in osteocyte mechanoregulation
2009-10 Rachel Tonelli-Zakaski Disused induced osteocyte apoptosis
2011-12 Sina Makaremi Design a flow-pressure chamber for osteocyte mechanobiology study
2013-14 Xiaoqing Zhang Mechanical regulation of bone microdamage
Avinash Kondiboyina Reynolds number effect on bone cell mechanosensitivity
2014-15   Lily Lau Fluid flow shear stress and pressure chamber design
Danny Cen Microfluidic channel design for cellular signaling analysis

2016-17             Xueting Mei                                                Microfluidic co-culture system design

                           Ouyan DongFang                                       Early detection of myeloma using microfluidic approach

4.4        Non-degree Continuing Education and Other Teaching

      List other teaching activities

Capstone design course MIE 491 project faculty advisor

2011-12:

Project: Linear Impact Tester

Team: Team 26. Team member: Shaheer Aziz, Jamin Patel, Brandon Ramsundar, Ravi Suri

     2016-17:

              Project: Small animal loading device

              Team: Team 45. Team member: Rahul Mitra, Dongfang Ouyang, Kevin Tu, Chun Wong.

     2017-18:

              Project: Paediatric AT-Knee Design, PROPEL Lab

              Team: DaEun Jeong, Dahlia Milevsky, Dongjun Lee, Fabricio Proano

     2018-19:

              Project: CleanSlate UV

              Team: Chan Ho Lee, Po Ting Chou, Heechan Kang, Donghoon Kim, Putthipat Preecharwongsiri.

Team won the Wallace G. Chalmers Scholarship for Best Design

     2019-20:

              Project: Pumping system for oscillatory flow in microfluidic system

              Team: Yichao Shi, Qianli Han, Zhaoji Tan, Zijian Cao

     2019-20:

              Project: Vibration platform for bone mechanobiology study

              Team: Tyler Campbell, Amir Kamaleddine, Matteo Kim, Mei Li.

Capstone design course APS 490 project faculty advisor \

2017-18:

Project: A First-order Physical Model of an Osteocyte in Cortical Bone

Team: Yizhou Chen, Benjamin Stordy, Mingfan Yang, Yiran Zou

     2018-19:

              Project: Lower Body Negative Pressure Suit

              Team: Pouya Ahmadian, Marco Montoya, Raem Naveed, Ariel Seebarran

Guest Lecture:

“Fluid flow in bone and mechanotransduction” to BME1450. March 13th, 2008

“Mechanotransduction” to MIE191. February 12, 2008.

“Fluid flow in bone and mechanotransduction” to BME1450. November 13th, 2009

“Review: Fluid Mechanics and Mass Transfer” to JTC1331, February 12, 2009

“Mechanotransduction” to MIE191. March 19, 2009.

“Mechanotransduction I – Mechanical Environment” to JTC1331, March 26, 2009

“Fluid flow in bone and mechanotransduction” to BME1450. November 13th, 2009

“Mechanotransduction” to MIE191. March 18, 2010.

“Mechanotransduction” to MIE191, April 15, 2012

“Mechanotransduction” to MSC3001H Foundations in Musculoskeletal Science, Nov. 21, 2014

“Bone Cell Cross Talk Under Mechanical Loading” to SRD4445H Doctoral Seminar Series, Oct. 25, 2016